Stomatin and sensory neuron mechanotransduction.

Stomatin and sensory neuron mechanotransduction. Research Abstract Details 

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Stomatin and sensory neuron mechanotransduction. Abstract Text:

Carlos Martinez-Salgado,Anne G Benckendorff,Li-Yang Chiang,Rui Wang,Nevena Milenkovic,Christiane Wetzel,Jing Hu,Cheryl L Stucky,Marilyn G Parra,Narla Mohandas,Gary R Lewin,Carlos Martinez-Salgado,Anne G Benckendorff,Li-Yang Chiang,Rui Wang,Nevena Milenkovic,Christiane Wetzel,Jing Hu,Cheryl L Stucky,Marilyn G Parra,Narla Mohandas,Gary R Lewin,

Somatic sensory neurons of the dorsal root ganglia are necessary for a large part of our mechanosensory experience. However, we only have a good knowledge of the molecules required for mechanotransduction in simple invertebrates such as the nematode Caenorhabiditis elegans. In C. elegans, a number of so-called mec genes have been isolated that are required for the transduction of body touch. One such gene, mec-2 codes for an integral membrane protein of the stomatin family, a large group of genes with a stomatin homology domain. Using stomatin null mutant mice, we have tested the hypothesis that the founding member of this family, stomatin might play a role in the transduction of mechanical stimuli by primary sensory neurons. We used the in vitro mouse skin nerve preparation to record from a large population of low- and high-threshold mechanoreceptors with myelinated A-fiber (n = 553) and unmyelinated C-fiber (n = 157) axons. One subtype of mechanoreceptor, the d-hair receptor, which is a rapidly adapting mechanoreceptor, had reduced sensitivity to mechanical stimulation in the absence of stomatin. Other cutaneous mechanoreceptors, including nociceptive C-fibers were not affected by the absence of a functional stomatin protein. Patch-clamp analysis of presumptive D-hair receptor mechanoreceptive neurons, which were identified by a characteristic rosette morphology in culture, showed no change in membrane excitability in the absence of the stomatin protein. We conclude that stomatin is required for normal mechanotransduction in a subpopulation of vertebrate sensory neurons.

Stomatin and sensory neuron mechanotransduction. Publishing Authors By Initials

C Martinez-Salgado,AG Benckendorff,LY Chiang,R Wang,N Milenkovic,C Wetzel,J Hu,CL Stucky,MG Parra,N Mohandas,GR Lewin,C Martinez-Salgado,AG Benckendorff,LY Chiang,R Wang,N Milenkovic,C Wetzel,J Hu,CL Stucky,MG Parra,N Mohandas,GR Lewin,

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Stomatin and sensory neuron mechanotransduction. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of neurophysiology

VOLUME: 98

Page Numbers: 3802-8

Journal Abbreviation: J. Neurophysiol.

ISSN: 0022-3077

DAY: 17

MONTH: 10

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Dept. of Neuroscience, Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin, Robert-Rössle Str., Berlin-Buch, D-13092, Germany. glewin@mdc-berlin.de).

Country: United States

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MEDLINETA: J Neurophysiol

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