Stimulus induced and seizure related changes in extracellular potassium concentration in cat thalamus (VPL).

Stimulus induced and seizure related changes in extracellular potassium concentration in cat thalamus (VPL). Research Abstract Details 

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Stimulus induced and seizure related changes in extracellular potassium concentration in cat thalamus (VPL). Abstract Text:

Extracellular potassium activity (ak) and field potentials (fp) were measured in the nucleus ventro-postero-lateralis (VPL) thalami in order to assess the extent of thalamic participation in cortical seizure activity. Small increases (up to 0.7 mmole/l) or decreases (up to 0.2 mmole/l) in ak were induced by electrical stimulation of the contralateral forepaw. These changes in ak were spatially more limited than the simultaneously recorded fp. Similar observations were made during weak electrical stimulation of the somatosensory cortex and during interictal spikes in a cortical penicillin focus. Large and widespread increases in ak to levels of 11.6 mmoles/l and slow negative fps of 8 mV accompanied seizure generation either in a cortical penicillin focus or during intense repetitive electrical stimulation of the cortical surface. Subsequent to such increases ak fell to subnormal levels. The amplitudes and durations of such undershoots were correlated with the amplitudes of the preceding increases in ak. Sometimes thalamic seizures ceases before cortical epileptic episodes. This resulted in a decrease of cortical EEG amplitudes. After ablation of the sensorimotor cortex seizures in forepaw-VPL could be induced by stimulation of the somatosensory cortex. These results further support the conclusion that specific thalamic nuclei participate in seizure generation and may serve as a subcortical route of seizure spread.

Stimulus induced and seizure related changes in extracellular potassium concentration in cat thalamus (VPL). Publishing Authors By Initials

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Stimulus induced and seizure related changes in extracellular potassium concentration in cat thalamus (VPL). Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Electroencephalography and clinical neurophysiolog

VOLUME: 47

Page Numbers: 329-44

Journal Abbreviation: Electroencephalogr Clin Neurop

ISSN: 0013-4694

DAY: 9

MONTH: Sep

YEAR: 1979

Stimulus induced and seizure related changes in extracellular potassium concentration in cat thalamus (VPL). Information

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LANGUAGE: eng

NlmUniqueID: 375035

Stimulus induced and seizure related changes in extracellular potassium concentration in cat thalamus (VPL). Keywords Mesh Terms:

KEYWORDS: Thalamic Nuclei

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Stimulus induced and seizure related changes in extracellular potassium concentration in cat thalamus (VPL). Information

Substance Name: Potassium

Registry Number: 7440-09-7

Grant and Affiliation Information for Stimulus induced and seizure related changes in extracellular potassium concentration in cat thalamus (VPL).

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Country: NETHERLANDS

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MEDLINETA: Electroencephalogr Clin Neurop

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