Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop.

Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop. Abstract Text:

Yin Chen,Philip Thai,Yu-Hua Zhao,Ye-Shih Ho,Mary M DeSouza,Reen Wu,

Mucus hypersecretion and persistent airway inflammation are common features of various airway diseases, such as asthma, chronic obstructive pulmonary disease, and cystic fibrosis. One key question is: does the associated airway inflammation in these diseases affect mucus production? If so, what is the underlying mechanism? It appears that increased mucus secretion results from increased mucin gene expression and is also frequently accompanied by an increased number of mucous cells (goblet cell hyperplasia/metaplasia) in the airway epithelium. Many studies on mucin gene expression have been directed toward Th2 cytokines such as interleukin (IL)-4, IL-9, and IL-13 because of their known pathophysiological role in allergic airway diseases such as asthma. However, the effect of these cytokines has not been definitely linked to their direct interaction with airway epithelial cells. In our study, we treated highly differentiated cultures of primary human tracheobronchial epithelial (TBE) cells with a panel of cytokines (interleukin-1alpha, 1beta, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 15, 16, 17, 18, and tumor necrosis factor alpha). We found that IL-6 and IL-17 could stimulate the mucin genes, MUC5B and MUC5AC. The Th2 cytokines IL-4, IL-9, and IL-13 did not stimulate MUC5AC or MUC5B in our experiments. A similar stimulation of MUC5B/Muc5b expression by IL-6 and IL-17 was demonstrated in primary monkey and mouse TBE cells. Further investigation of MUC5B expression demonstrated that IL-17's effect is at least partly mediated through IL-6 by a JAK2-dependent autocrine/paracrine loop. Finally, evidence is presented to show that both IL-6 and IL-17 mediate MUC5B expression through the ERK signaling pathway.

Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop. Publishing Authors By Initials

Y Chen,P Thai,YH Zhao,YS Ho,MM DeSouza,R Wu,

For similar respiratory system: respiratory mucosa research abstracts see: respiratory system: respiratory mucosa research

PUBMED ID PMID:

MEDLINE DATE:

Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of biological chemistry

VOLUME: 278

Page Numbers: 17036-43

Journal Abbreviation: J. Biol. Chem.

ISSN: 0021-9258

DAY: 6

MONTH: 03

YEAR: 2003

Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985121

Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop. Keywords Mesh Terms:

KEYWORDS: Respiratory Mucosa

MESH TERMS: physiology

Chemical & Substance for Abstract: Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop. Information

Substance Name: mucin 5AC

Registry Number: 0

Grant and Affiliation Information for Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop.

AFFILIATION: Center for Comparative Respiratory Biology and Medicine, University of California, Davis, California 95616, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL35635

ACRONYM: HL

MEDLINETA: J Biol Chem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Stimulation of airway mucin gene expression by interleukin IL-17 through IL-6 paracrine/autocrine loop Related Publications

• Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5'-flanking region.
• Clinical analysis of 4 cases of juvenile granulosa cell tumor of the ovary.
• Differential regulation of airway mucin gene expression and mucin secretion by extracellular nucleotide triphosphates.
• Effects of As(2)O(3) on BCR-ABL protein level and signal transduction in CML cells.
• Etiological analysis on the ocular fungal infection.
• Expression of mPer1 and mPer2, two mammalian clock genes, in murine bone marrow.
• Monocyte chemoattractant protein-1 mRNA in human intracranial aneurysm walls.
• Roles of kappa opioid receptors in cardioprotection against ischemia: the signaling mechanisms.
• Significance of HER-2/neu expression in ovarian epithelial tumours.
• Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop.
• Study on some mechanism of leucite microcrystallization to reinforce dental glass ceramics.
• The clinical study of lateral orbitotomy.
• The expression, characterization and roles of macrophage colony-stimulating factor receptor in human leukemia cell lines.
• Thermal hyperalgesic effects induced by intracerebroventricular injection of interleukin-1beta in rats.
• [Arsenic exposure of residents in areas near Shimen arsenic mine]
• [Clinical study of treatment with continuous renal replacement therapy on severe hepatitis with hepatic encephalopathy]
• [Content of metals in different diameter airborne particles and effect on micronuclei formation in human lymphocytes]
• [Detection of monosomy 7 or 7q- in cases of myelodysplastic syndrome]
• [Determination of triptolide in tripterygium preparations by gradient high performance liquid chromatography]
• [Discussion on the concept problem of the specific retention volume in gas chromatography]
• [Effect of recombinant human bone morphogenetic protein-2 on the expression of osteopontin in human periodontal ligament cells]
• [Liver sinusoidal endothelial cell damage during normothermic ischemia and reperfusion of rat]
• [Oral combination chemotherapy of 5'-deoxy-5-fluorouridine (furtulon) and cyclophosphamide for advanced breast cancer]
• [Pathological features of atrial isomerism and its diagnosis by computed tomography]
• [Preliminary study on the molecular mechanism of K562 cell apoptosis induced by As2S2]
• [Relationship between apolipoprotein E and apolipoprotein B polymorphisms in youths with coronary heart disease]
• [Screening and identification of egg mimotope of Schistosoma japonicum]
• [Studies on immunoprotection in mice after immunization with Schistosoma japonicum 22.6 kDa recombinant protein]
• [Study of acute physiology and chronic health evaluation III and multiple organ dysfunction syndrome score in evaluating severity of intensive care units patient]
• [Study on hepatic-protective effect of "yinzhihuang" granula]