Stimulation by melanocyte stimulating hormone and dibutyryl adenosine 3'5'-cyclic monophosphate of DNA synthesis in human melanocytes in vitro.

Stimulation by melanocyte stimulating hormone and dibutyryl adenosine 3'5'-cyclic monophosphate of DNA synthesis in human melanocytes in vitro. Research Abstract Details 

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Stimulation by melanocyte stimulating hormone and dibutyryl adenosine 3'5'-cyclic monophosphate of DNA synthesis in human melanocytes in vitro. Abstract Text:

The proliferation of human melanocytes in vitro was stimulated by MSH. This stimulation was further intensified by the simultaneous addition of theophylline with MSH. Theophylline alone stimulated proliferation moderately. Dibutyryl cyclic AMP strongly stimulated the proliferation, but sodium butyrate, 5'-AMP and cGMP did not. The stimulation by dibutyryl cyclic AMP was continued up to 4 days so far tested. These findings are directly opposed to those on mouse melanoma cells in culture which responded with retarded growth to MSH and cyclic AMP. It is suggested that the difference of proliferation control may explain the different reaction of the melanocyte and the melanoma cells. The epidermal melanocytes seem to belong to the exceptional group of the cells which responded to cyclic AMP with accelerated proliferation.

Stimulation by melanocyte stimulating hormone and dibutyryl adenosine 3'5'-cyclic monophosphate of DNA synthesis in human melanocytes in vitro. Publishing Authors By Initials

For similar heterocyclic compounds: alkaloids: xanthines: theophylline research abstracts see: heterocyclic compounds: alkaloids: xanthines: theophylline research

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Stimulation by melanocyte stimulating hormone and dibutyryl adenosine 3'5'-cyclic monophosphate of DNA synthesis in human melanocytes in vitro. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives for dermatological research. Archiv für d

VOLUME: 257

Page Numbers: 47-52

Journal Abbreviation:

ISSN: 0340-3696

DAY: 26

MONTH: Nov

YEAR: 1976

Stimulation by melanocyte stimulating hormone and dibutyryl adenosine 3'5'-cyclic monophosphate of DNA synthesis in human melanocytes in vitro. Information

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LANGUAGE: eng

NlmUniqueID: 7512589

Stimulation by melanocyte stimulating hormone and dibutyryl adenosine 3'5'-cyclic monophosphate of DNA synthesis in human melanocytes in vitro. Keywords Mesh Terms:

KEYWORDS: Theophylline

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Stimulation by melanocyte stimulating hormone and dibutyryl adenosine 3'5'-cyclic monophosphate of DNA synthesis in human melanocytes in vitro. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Stimulation by melanocyte stimulating hormone and dibutyryl adenosine 3'5'-cyclic monophosphate of DNA synthesis in human melanocytes in vitro.

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Country: GERMANY, WEST

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MEDLINETA: Arch Dermatol Res

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