Stereotactic radiofrequency thermocoagulation for hypothalamic hamartoma with intractable gelastic seizures.

Stereotactic radiofrequency thermocoagulation for hypothalamic hamartoma with intractable gelastic seizures. Research Abstract Details 

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Stereotactic radiofrequency thermocoagulation for hypothalamic hamartoma with intractable gelastic seizures. Abstract Text:

Junpei Homma,Shigeki Kameyama,Hiroshi Masuda,Takehiko Ueno,Ayataka Fujimoto,Makoto Oishi,Masafumi Fukuda,Junpei Homma,Shigeki Kameyama,Hiroshi Masuda,Takehiko Ueno,Ayataka Fujimoto,Makoto Oishi,Masafumi Fukuda,

Management of hypothalamic hamartoma with intractable gelastic epilepsy remains controversial. We have used stereotactic thermocoagulation for treatment of hypothalamic hamartoma with intractable gelastic epilepsy since 1997. Herein, we review our experience in five cases to clarify the usefulness of this treatment. A total of five patients with hypothalamic hamartoma were treated by stereotactic thermocoagulation at our hospital during the period October 1997 through February 2004. In all patients, the hamartoma was less than 10mm in diameter and was located on the floor of the third ventricle with sessile attachment to the wall. To identify ictal onset, chronic intracranial electroencephalography was performed in three patients with the use of a depth electrode implanted in the hamartoma. Attempts were made to induce gelastic seizure by electrical stimulation of the hamartoma in three patients. After magnetic resonance imaging-guided targeting, radiofrequency thermocoagulation of the boundary between the hamartoma and normal hypothalamus was performed to achieve disconnection effects. Marked reductions in seizure frequency were obtained in all cases, with three patients becoming seizure-free after the procedure. No intraoperative complications occurred except in one patient who experienced acute and transient panidrosis with hot flushes during coagulation. Our results suggest that stereotactic thermocoagulation of hypothalamic hamartoma is an acceptable treatment option for patients with intractable gelastic seizures.

Stereotactic radiofrequency thermocoagulation for hypothalamic hamartoma with intractable gelastic seizures. Publishing Authors By Initials

J Homma,S Kameyama,H Masuda,T Ueno,A Fujimoto,M Oishi,M Fukuda,J Homma,S Kameyama,H Masuda,T Ueno,A Fujimoto,M Oishi,M Fukuda,

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Stereotactic radiofrequency thermocoagulation for hypothalamic hamartoma with intractable gelastic seizures. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Epilepsy research

VOLUME: 76

Page Numbers: 15-21

Journal Abbreviation: Epilepsy Res.

ISSN: 0920-1211

DAY: 23

MONTH: 07

YEAR: 2007

Stereotactic radiofrequency thermocoagulation for hypothalamic hamartoma with intractable gelastic seizures. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Stereotactic radiofrequency thermocoagulation for hypothalamic hamartoma with intractable gelastic seizures.

AFFILIATION: Department of Neurosurgery, Epilepsy Center, Nishi-Niigata Chuo National Hospital, 1-14-1 Masago, Niigata 950-2085, Japan.

Country: Netherlands

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MEDLINETA: Epilepsy Res

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