Stereospecificity of conversion of uric acid into allantoic acid by enzymes of Canadida utilis.

Stereospecificity of conversion of uric acid into allantoic acid by enzymes of Canadida utilis. Research Abstract Details 

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Stereospecificity of conversion of uric acid into allantoic acid by enzymes of Canadida utilis. Abstract Text:

I Okumura,K Kondo,Y Miyake,K Itaya,T Yamamoto,

1. Allantoinase [EC 3.5.2.5] was isolated from cells of Candida utilis and unpurified by chromatography on columns of DEAE-cellulose and Sephadex G-200 after treatment with urea to remove urate oxidase [EC 1.7.3.3.]. 2. The purified allantoinase catalyzed the hydrolysis of allantoin into allantoic acid. However, only half of the allantoin produced from uric acid by urate oxidase was converted. The rest of the allantoin was unchanged, and showed a negative optical rotation. 3. On the other hand, the combined action of crude urate oxidase and allantoinase resulted in nearly complete conversion of uric acid into allantoic acid. Furthermore, the unpurified allantoinase preparation hydrolyzed racemic allantoin to allantoic acid completely. 4. These results indicate that the urate oxidase produces racemic allantoin from uric acid and that the allantoinase attacks only allantoin of positive optical rotation. The results also suggest that allantoin racemase is present in the yeast cells.

Stereospecificity of conversion of uric acid into allantoic acid by enzymes of Canadida utilis. Publishing Authors By Initials

I Okumura,K Kondo,Y Miyake,K Itaya,T Yamamoto,

For similar enzymes and coenzymes: enzymes: oxidoreductases: urate oxidase research abstracts see: enzymes and coenzymes: enzymes: oxidoreductases: urate oxidase research

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Stereospecificity of conversion of uric acid into allantoic acid by enzymes of Canadida utilis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 79

Page Numbers: 1013-9

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: May

YEAR: 1976

Stereospecificity of conversion of uric acid into allantoic acid by enzymes of Canadida utilis. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Stereospecificity of conversion of uric acid into allantoic acid by enzymes of Canadida utilis. Keywords Mesh Terms:

KEYWORDS: Urate Oxidase

MESH TERMS: metabolism

Chemical & Substance for Abstract: Stereospecificity of conversion of uric acid into allantoic acid by enzymes of Canadida utilis. Information

Substance Name: Amidohydrolases

Registry Number: EC 3.5.-

Grant and Affiliation Information for Stereospecificity of conversion of uric acid into allantoic acid by enzymes of Canadida utilis.

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Country: JAPAN

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MEDLINETA: J Biochem

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