Stereoselective synthesis and cytotoxicity of a cancer chemopreventive naphthoquinone from Tabebuia avellanedae.

Stereoselective synthesis and cytotoxicity of a cancer chemopreventive naphthoquinone from Tabebuia avellanedae. Research Abstract Details 

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Stereoselective synthesis and cytotoxicity of a cancer chemopreventive naphthoquinone from Tabebuia avellanedae. Abstract Text:

Mitsuaki Yamashita,Masafumi Kaneko,Akira Iida,Harukuni Tokuda,Katsumi Nishimura,Mitsuaki Yamashita,Masafumi Kaneko,Akira Iida,Harukuni Tokuda,Katsumi Nishimura,

Stereoselective synthesis of 1, one of biologically active naphthoquinones from a Brazilian traditional medicine Tabebuia avellanedae, was achieved by utilizing Noyori reduction as a key step. Compound 1 displayed potent cytotoxicity against several human tumor cell lines, whereas it showed lower cytotoxicity against some human normal cell lines compared with that of mitomycin. On the other hand, its enantiomer was less active toward the tumor cell lines than 1.

Stereoselective synthesis and cytotoxicity of a cancer chemopreventive naphthoquinone from Tabebuia avellanedae. Publishing Authors By Initials

M Yamashita,M Kaneko,A Iida,H Tokuda,K Nishimura,M Yamashita,M Kaneko,A Iida,H Tokuda,K Nishimura,

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Stereoselective synthesis and cytotoxicity of a cancer chemopreventive naphthoquinone from Tabebuia avellanedae. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 6417-20

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 5

MONTH: 10

YEAR: 2007

Stereoselective synthesis and cytotoxicity of a cancer chemopreventive naphthoquinone from Tabebuia avellanedae. Information

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LANGUAGE: eng

NlmUniqueID: 9107377

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Grant and Affiliation Information for Stereoselective synthesis and cytotoxicity of a cancer chemopreventive naphthoquinone from Tabebuia avellanedae.

AFFILIATION: Faculty of Pharmacy, Takasaki University of Health and Welfare, Nakaorui-machi, Takasaki 370-0033, Japan.

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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