Stereoselective reductase-catalysed deoxygenation of sulfoxides in aerobic and anaerobic bacteria.

Stereoselective reductase-catalysed deoxygenation of sulfoxides in aerobic and anaerobic bacteria. Research Abstract Details 

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Stereoselective reductase-catalysed deoxygenation of sulfoxides in aerobic and anaerobic bacteria. Abstract Text:

Derek R Boyd,Narain D Sharma,Alistair W T King,Steven D Shepherd,Christopher C R Allen,Robert A Holt,Heather R Luckarift,Howard Dalton,

Direct and indirect evidence, of unexpected stereoselective reductase-catalysed deoxygenations of sulfoxides, was found. The deoxygenations proceeded simultaneously, with the expected dioxygenase-catalysed asymmetric sulfoxidation of sulfides, during some biotransformations with the aerobic bacterium Pseudomonas putida UV4. Stereoselective reductase-catalysed asymmetric deoxygenation of racemic alkylaryl, dialkyl and phenolic sulfoxides was observed, without evidence of the reverse sulfoxidation reaction, using anaerobic bacterial strains. A purified dimethyl sulfoxide reductase, obtained from the intact cells of the anaerobic bacterium Citrobacter braakii DMSO 11, yielded, from the corresponding racemates, enantiopure alkylaryl sulfoxide and thiosulfinate samples.

Stereoselective reductase-catalysed deoxygenation of sulfoxides in aerobic and anaerobic bacteria. Publishing Authors By Initials

DR Boyd,ND Sharma,AW King,SD Shepherd,CC Allen,RA Holt,HR Luckarift,H Dalton,

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Stereoselective reductase-catalysed deoxygenation of sulfoxides in aerobic and anaerobic bacteria. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Organic & biomolecular chemistry

VOLUME: 2

Page Numbers: 554-61

Journal Abbreviation: Org. Biomol. Chem.

ISSN: 1477-0520

DAY: 16

MONTH: 01

YEAR: 2004

Stereoselective reductase-catalysed deoxygenation of sulfoxides in aerobic and anaerobic bacteria. Information

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LANGUAGE: eng

NlmUniqueID: 101154995

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Grant and Affiliation Information for Stereoselective reductase-catalysed deoxygenation of sulfoxides in aerobic and anaerobic bacteria.

AFFILIATION: School of Chemistry, The Queen's University of Belfast, Belfast, UK.

Country: England

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MEDLINETA: Org Biomol Chem

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