Stereochemistry of guanidine-metal interactions: implications for L-arginine-metal interactions in protein structure and function.

Stereochemistry of guanidine-metal interactions: implications for L-arginine-metal interactions in protein structure and function. Research Abstract Details 

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Stereochemistry of guanidine-metal interactions: implications for L-arginine-metal interactions in protein structure and function. Abstract Text:

Luigi Di Costanzo,Lloyd V Flores,David W Christianson,

The geometries of 150 guanidine-metal ion interactions retrieved from crystal structures deposited in the Cambridge Structural Database have been analyzed. Metal ions exhibit a preference for anti coordination stereochemistry in the plane of the unprotonated guanidine group, usually in chelate complexes with a diguanidine moiety, but syn-oriented interactions are occasionally found for single guanidine-metal interactions. Three L-arginine-metal coordination interactions are found in metalloenzyme structures deposited in the Protein Data Bank: biotin synthase from E. coli, His-67 --> Arg human carbonic anhydrase I, and inactivated B. caldovelox arginase complexed with L-arginine. In these proteins, L-arginine-metal coordination adopts syn/out-of-plane and anti/in-plane coordination stereochemistry. The implications of these results for L-arginine-metal interactions in protein structure and function are discussed. Although such interactions are rare, this analysis serves as a useful reference point for the growing interest in enzymes containing L-arginine residues that function as general bases or metal ligands.

Stereochemistry of guanidine-metal interactions: implications for L-arginine-metal interactions in protein structure and function. Publishing Authors By Initials

L Di Costanzo,LV Flores,DW Christianson,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research

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Stereochemistry of guanidine-metal interactions: implications for L-arginine-metal interactions in protein structure and function. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proteins

VOLUME: 65

Page Numbers: 637-42

Journal Abbreviation: Proteins

ISSN: 1097-0134

DAY: 15

MONTH: Nov

YEAR: 2006

Stereochemistry of guanidine-metal interactions: implications for L-arginine-metal interactions in protein structure and function. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8700181

Stereochemistry of guanidine-metal interactions: implications for L-arginine-metal interactions in protein structure and function. Keywords Mesh Terms:

KEYWORDS: Structure-Activity Relationship

MESH TERMS: metabolism

Chemical & Substance for Abstract: Stereochemistry of guanidine-metal interactions: implications for L-arginine-metal interactions in protein structure and function. Information

Substance Name: Arginine

Registry Number: 74-79-3

Grant and Affiliation Information for Stereochemistry of guanidine-metal interactions: implications for L-arginine-metal interactions in protein structure and function.

AFFILIATION: Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM49758

ACRONYM: GM

MEDLINETA: Proteins

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