Stereochemistry of biopterin cofactor and facile methods for the determination of the stereochemistry of a biologically active 5,6,7,8-tetrahydropterin.

Stereochemistry of biopterin cofactor and facile methods for the determination of the stereochemistry of a biologically active 5,6,7,8-tetrahydropterin. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Stereochemistry of biopterin cofactor and facile methods for the determination of the stereochemistry of a biologically active 5,6,7,8-tetrahydropterin. Abstract Text:

S Matsuura,T Sugimoto,S Murata,Y Sugawara,H Iwasaki,

The structure of (-)-tetrahydrobiopterin, the cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases, was determined as (6R, 1'R, 2'S)-6-(1',2'-dihydroxypropyl)-5,6,7,8-tetrahydropterin by X-ray crystallographic analysis. The CD spectra of (-)-tetrahydrobiopterin exhibits a negative Cotton effect at 290-240 nm in pH 3.2 solution. The relationship of the negative Cotton effect and the 6R configuration was supported by the application of CD analysis with 2-methyltetrahydronaphthalene as a model compound. The stereochemistries at the C(6) position of various biologically active 6-substituted tetrahydropterins were determined from the CD spectra. The relative configuration of two asymmetric centers, C(6), and C(1'), was determined by HPLC analysis on a strong cation exchange column.

Stereochemistry of biopterin cofactor and facile methods for the determination of the stereochemistry of a biologically active 5,6,7,8-tetrahydropterin. Publishing Authors By Initials

S Matsuura,T Sugimoto,S Murata,Y Sugawara,H Iwasaki,

For similar investigative techniques: chemistry, analytical: crystallography: x-ray diffraction research abstracts see: investigative techniques: chemistry, analytical: crystallography: x-ray diffraction research

PUBMED ID PMID:

MEDLINE DATE:

Stereochemistry of biopterin cofactor and facile methods for the determination of the stereochemistry of a biologically active 5,6,7,8-tetrahydropterin. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 98

Page Numbers: 1341-8

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Nov

YEAR: 1985

Stereochemistry of biopterin cofactor and facile methods for the determination of the stereochemistry of a biologically active 5,6,7,8-tetrahydropterin. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376600

Stereochemistry of biopterin cofactor and facile methods for the determination of the stereochemistry of a biologically active 5,6,7,8-tetrahydropterin. Keywords Mesh Terms:

KEYWORDS: X-Ray Diffraction

MESH TERMS: analysis

Chemical & Substance for Abstract: Stereochemistry of biopterin cofactor and facile methods for the determination of the stereochemistry of a biologically active 5,6,7,8-tetrahydropterin. Information

Substance Name: Biopterin

Registry Number: 22150-76-1

Grant and Affiliation Information for Stereochemistry of biopterin cofactor and facile methods for the determination of the stereochemistry of a biologically active 5,6,7,8-tetrahydropterin.

AFFILIATION:

Country: JAPAN

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Biochem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Stereochemistry of biopterin cofactor and facile methods for the determination of the stereochemistry of a biologically active 5,6,7,8-tetrahydropterin Related Publications

• A case report of very late thrombosis of coronary bare-metal stent 10 years after stenting.
• Acute exacerbation of idiopathic pulmonary fibrosis: role of Chlamydophila pneumoniae infection.
• Application of an Imaging Plate to the Large-Volume Press MAX80 at the Photon Factory.
• Approach to predict the contribution of cytochrome P450 enzymes to drug metabolism in the early drug-discovery stage: the effect of the expression of cytochrome b(5) with recombinant P450 enzymes.
• Circadian gene expression of clock genes and plasminogen activator inhibitor-1 in heart and aorta of spontaneously hypertensive and Wistar-Kyoto rats.
• Compositional characteristics and hardness of acrylic and composite resin artificial teeth.
• Cutting Edge: Plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ.
• Direct separation of regioisomers and enantiomers of monoacylglycerols by tandem column high-performance liquid chromatography.
• Double lumen tube placement with the Pentax-Airway Scope.
• Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells.
• Fission yeast Swi5 protein, a novel DNA recombination mediator.
• Imaging polarimetry and retinal blood vessel quantification at the epiretinal membrane.
• Innate control of adaptive immunity: dendritic cells and beyond.
• Metabolism of CJ-036878, N-(3-phenethoxybenzyl)-4-hydroxybenzamide, in liver microsomes and recombinant cytochrome P450 enzymes: metabolite identification by LC-UV/MS(n) and (1)H-NMR.
• Metabolism of tacrolimus (FK506) and recent topics in clinical pharmacokinetics.
• Mucosal dendritic cells.
• Multiple Sclerosis in a Division I Football Player: 1155: June 2 10:40 AM - 11:00 AM.
• Radiological findings, clinical course, and outcome in asymptomatic moyamoya disease: results of multicenter survey in Japan.
• Rapid mapping of texture in polycrystalline materials using an imaging plate on a synchrotron radiation source.
• Relationship between retinal vein occlusion and carotid artery lesions.
• Role of SDF-1/CXCR4 system in survival and migration of bone marrow stromal cells after transplantation into mice cerebral infarct.
• Systems-level modeling of neuronal circuits for leech swimming.
• The Parker Flex-Tiptrade mark tracheal tube makes endotracheal intubation with the Bullard laryngoscope easier and faster.
• The post-operative changes in the level of inflammatory markers after posterior lumbar interbody fusion.
• Three-dimensional architecture of virus-packed tubule.
• Upregulation of neurotrophic factor-related gene expression in retina with experimental autoimmune uveoretinitis by intravitreal injection of tacrolimus (FK506).
• Use of plate-wash samples to monitor the fates of culturable bacteria in mercury- and trichloroethylene-contaminated soils.
• Vaginal epithelial dendritic cells renew from bone marrow precursors.
• [Method of evaluating masticatory function at swallowing threshold for complete denture wearers.]
• [Pathophysiology of cognitive impairment after diffuse brain injury: the prospects for cell transplantation therapy]