Stereochemical identification of (R)- and (S)-ibuprofen using residual dipolar couplings, NMR, and modeling.

Stereochemical identification of (R)- and (S)-ibuprofen using residual dipolar couplings, NMR, and modeling. Research Abstract Details 

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Stereochemical identification of (R)- and (S)-ibuprofen using residual dipolar couplings, NMR, and modeling. Abstract Text:

Vasilios M Marathias,Gregory J Tawa,Igor Goljer,Alvin C Bach,Vasilios M Marathias,Gregory J Tawa,Igor Goljer,Alvin C Bach,

In this work, we describe an NMR-based method that utilizes an orientation media composed of the chiral polypeptide liquid crystal poly-gamma-benzyl-L-glutamate (PBLG) dissolved in CDCl(3), to measure the (1)H-(1)H, (1)H-(13)C and (13)C-(13)C residual dipolar couplings (RDCs) of (R) and (S)-ibuprofen. Calculated RDCs, obtained from the lowest energy conformers, are then compared with the experimentally measured RDCs to predict the stereochemistry of each enantiomer. Excellent agreement between calculated and experimental RDCs was found when the lowest energy structure of each enantiomer, obtained in a simulated PBLG/CDCl(3) environment, was used to back-calculate the RDCs. This method is generally useful for small molecular weight molecules that possess either one or two chiral centers, are soluble in low viscosity organic solvents, and will not crystallize (Clegg, Crystal Structure Analysis. Principles and Practice. New York: Oxford University Press; 2002) or cannot be derivatized with a Mosher's reagent (Dale and Mosher, J Am Chem Soc 1973;95:512-519).

Stereochemical identification of (R)- and (S)-ibuprofen using residual dipolar couplings, NMR, and modeling. Publishing Authors By Initials

VM Marathias,GJ Tawa,I Goljer,AC Bach,VM Marathias,GJ Tawa,I Goljer,AC Bach,

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Stereochemical identification of (R)- and (S)-ibuprofen using residual dipolar couplings, NMR, and modeling. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Chirality

VOLUME: 19

Page Numbers: 741-50

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ISSN: 0899-0042

DAY: 20

MONTH: Sep

YEAR: 2007

Stereochemical identification of (R)- and (S)-ibuprofen using residual dipolar couplings, NMR, and modeling. Information

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LANGUAGE: eng

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AFFILIATION: Discovery Analytical Chemistry, Chemical and Screening Sciences, Wyeth Research, Princeton, NJ 08543-8000, USA. marathv@wyeth.com

Country: United States

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MEDLINETA: Chirality

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