Stem cells in liver regeneration and therapy.

Stem cells in liver regeneration and therapy. Research Abstract Details 

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Stem cells in liver regeneration and therapy. Abstract Text:

Tobias Cantz,Michael P Manns,Michael Ott,

The liver has adapted to the inflow of ingested toxins by the evolutionary development of unique regenerative properties and responds to injury or tissue loss by the rapid division of mature cells. Proliferation of the parenchymal cells, i.e. hepatocytes and epithelial cells of the bile duct, is regulated by numerous cytokine/growth-factor-mediated pathways and is synchronised with extracellular matrix degradation and restoration of the vasculature. Resident hepatic stem/progenitor cells have also been identified in small numbers in normal liver and implicated in liver tissue repair. Their putative role in the physiology, pathophysiology and therapy of the liver, however, is not yet precisely known. Hepatic stem/progenitor cells also known as "oval cells" in rodents have been implicated in liver tissue repair, at a time when the capacity for hepatocyte and bile duct replication is exhausted or experimentally inhibited (facultative stem/progenitor cell pool). Although much more has to be learned about the role of stem/progenitor cells in the physiology and pathophysiology of the liver, experimental analysis of the therapeutic value of these cells has been initiated. Transplantation of hepatic stem/progenitor cells or in vivo pharmacological activation of the pool of hepatic stem cells may provide novel modalities for the therapy of liver diseases. In addition, extrahepatic stem cells (e.g. bone marrow cells) are being investigated for their contribution to liver regeneration. Hepatic progenitor cells derived from embryonic stem cells are included in this review, which also discusses future perspectives of stem cell-based therapies for liver diseases.

Stem cells in liver regeneration and therapy. Publishing Authors By Initials

T Cantz,MP Manns,M Ott,

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Stem cells in liver regeneration and therapy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cell and tissue research

VOLUME: 331

Page Numbers: 271-82

Journal Abbreviation: Cell Tissue Res.

ISSN: 0302-766X

DAY: 28

MONTH: 09

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Max-Planck-Institute for Molecular Biomedicine, Muenster, Germany.

Country: Germany

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MEDLINETA: Cell Tissue Res

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