Stem cells and the regeneration of the aging cardiovascular system.

Stem cells and the regeneration of the aging cardiovascular system. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Stem cells and the regeneration of the aging cardiovascular system. Abstract Text:

Victoria L T Ballard,Jay M Edelberg,

It is well established that cardiovascular repair mechanisms become progressively impaired with age and that advanced age is itself a significant risk factor for cardiovascular disease. Although therapeutic developments have improved the prognosis for those with cardiovascular disease, mortality rates have nevertheless remained virtually unchanged in the last twenty years. Clearly, there is a need for alternative strategies for the treatment of cardiovascular disease. In recent years, the idea that the heart is capable of regeneration has raised the possibility that cell-based therapies may provide such an alternative to conventional treatments. Cells that have the potential to generate cardiomyocytes and vascular cells have been identified in both the adult heart and peripheral tissues, and in vivo experiments suggest that these cardiovascular stem cells and cardiovascular progenitor cells, including endothelial progenitor cells, are capable of replacing damaged myocardium and vascular tissues. Despite these findings, the endogenous actions of cardiovascular stem cells and cardiovascular progenitor cells appear to be insufficient to protect against cardiovascular disease in older individuals. Because recent evidence suggests that cardiovascular stem cells and cardiovascular progenitor cells are subject to age-associated changes that impair their function, these changes may contribute to the dysregulation of endogenous cardiovascular repair mechanisms in the aging heart and vasculature. Here we present the evidence for the impact of aging on cardiovascular stem cell/cardiovascular progenitor cell function and its potential importance in the increased severity of cardiovascular pathophysiology observed in the geriatric population.

Stem cells and the regeneration of the aging cardiovascular system. Publishing Authors By Initials

VL Ballard,JM Edelberg,

For similar cells: stem cells research abstracts see: cells: stem cells research

PUBMED ID PMID:

MEDLINE DATE:

Stem cells and the regeneration of the aging cardiovascular system. Journal Published:

PUBLICATION TYPE: Review

Journal: Circulation research

VOLUME: 100

Page Numbers: 1116-27

Journal Abbreviation:

ISSN: 1524-4571

DAY: 27

MONTH: Apr

YEAR: 2007

Stem cells and the regeneration of the aging cardiovascular system. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 47103

Stem cells and the regeneration of the aging cardiovascular system. Keywords Mesh Terms:

KEYWORDS: Stem Cells

MESH TERMS: physiology

Chemical & Substance for Abstract: Stem cells and the regeneration of the aging cardiovascular system. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Stem cells and the regeneration of the aging cardiovascular system.

AFFILIATION: Department of Medicine, Weill Medical College of Cornell University, New York, USA.

Country: United States

AGENCY: United States NIA

GRANT: AG19738

ACRONYM: AG

MEDLINETA: Circ Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Stem cells and the regeneration of the aging cardiovascular system Related Publications

• Age-related differences in repair of dermal wounds and myocardial infarcts attenuate during the later stages of healing.
• Bone marrow Oct3/4+ cells differentiate into cardiac myocytes via age-dependent paracrine mechanisms.
• ELECTROPHYSIOLOGIC CHARACTERISTICS AND INTERPRETATION OF SKIN POTENTIALS. TECHN DOCUM REP SAM-TDR-63-95.
• Endothelial precursor cells.
• Stem cells and the regeneration of the aging cardiovascular system.
• Targets for regulating angiogenesis in the ageing endothelium.
• [Polycarboxylate cements]