Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease.

Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. Research Abstract Details 

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Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. Abstract Text:

Jean-Pyo Lee,Mylvaganam Jeyakumar,Rodolfo Gonzalez,Hiroto Takahashi,Pei-Jen Lee,Rena C Baek,Dan Clark,Heather Rose,Gerald Fu,Jonathan Clarke,Scott McKercher,Jennifer Meerloo,Franz-Josef Muller,Kook In Park,Terry D Butters,Raymond A Dwek,Philip Schwartz,Gang Tong,David Wenger,Stuart A Lipton,Thomas N Seyfried,Frances M Platt,Evan Y Snyder,

Intracranial transplantation of neural stem cells (NSCs) delayed disease onset, preserved motor function, reduced pathology and prolonged survival in a mouse model of Sandhoff disease, a lethal gangliosidosis. Although donor-derived neurons were electrophysiologically active within chimeric regions, the small degree of neuronal replacement alone could not account for the improvement. NSCs also increased brain beta-hexosaminidase levels, reduced ganglioside storage and diminished activated microgliosis. Additionally, when oral glycosphingolipid biosynthesis inhibitors (beta-hexosaminidase substrate inhibitors) were combined with NSC transplantation, substantial synergy resulted. Efficacy extended to human NSCs, both to those isolated directly from the central nervous system (CNS) and to those derived secondarily from embryonic stem cells. Appreciating that NSCs exhibit a broad repertoire of potentially therapeutic actions, of which neuronal replacement is but one, may help in formulating rational multimodal strategies for the treatment of neurodegenerative diseases.

Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. Publishing Authors By Initials

JP Lee,M Jeyakumar,R Gonzalez,H Takahashi,PJ Lee,RC Baek,D Clark,H Rose,G Fu,J Clarke,S McKercher,J Meerloo,FJ Muller,KI Park,TD Butters,RA Dwek,P Schwartz,G Tong,D Wenger,SA Lipton,TN Seyfried,FM Platt,EY Snyder,

For similar enzymes and coenzymes: enzymes: hydrolases: glycoside hydrolases: hexosaminidases: beta-n-acetylhexosaminidases research abstracts see: enzymes and coenzymes: enzymes: hydrolases: glycoside hydrolases: hexosaminidases: beta-n-acetylhexosaminidases research

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Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nature medicine

VOLUME: 13

Page Numbers: 439-47

Journal Abbreviation:

ISSN: 1078-8956

DAY: 11

MONTH: 03

YEAR: 2007

Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. Information

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LANGUAGE: eng

NlmUniqueID: 9502015

Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. Keywords Mesh Terms:

KEYWORDS: beta-N-Acetylhexosaminidases

MESH TERMS: metabolism

Chemical & Substance for Abstract: Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. Information

Substance Name: beta-N-Acetylhexosaminidases

Registry Number: EC 3.2.1.52

Grant and Affiliation Information for Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease.

AFFILIATION: Stem Cell & Regeneration Program, Center for Neuroscience and Aging Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA.

Country: United States

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MEDLINETA: Nat Med

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