Steady state dendritic cells with forced IDO expression induce skin allograft tolerance by upregulation of regulatory T cells.

Steady state dendritic cells with forced IDO expression induce skin allograft tolerance by upregulation of regulatory T cells. Research Abstract Details 

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Steady state dendritic cells with forced IDO expression induce skin allograft tolerance by upregulation of regulatory T cells. Abstract Text:

Guang Yu,Min Fang,Min Gong,Li Liu,Jixin Zhong,Wei Feng,Ping Xiong,Cong-Yi Wang,Feili Gong,Guang Yu,Min Fang,Min Gong,Li Liu,Jixin Zhong,Wei Feng,Ping Xiong,Cong-Yi Wang,Feili Gong,

Despite recent extensive studies, the molecular mechanism through which DCs induce allograft tolerance largely remains poorly understood. In the current study, we presented strong evidence supporting a role for IDO in DC-mediated allograft tolerance. Pre-treatment of recipient mice with IDO-transduced donor-specific BMDCs induced skin allograft tolerance in an antigen-dependent manner. Our data suggest that IDO-expressing DCs may regulate a delicate balance of cytokines that favors the differentiation of naïve CD4(+) T cells into Tregs instead of CD4(+) effector T cells. In addition, BMDCs with forced IDO expression also have higher capability to expand natural Tregs. In consistent with the observation of augmented Tregs detected in the recipient mice, the capacity for splenic T cell alloresponse was significantly reduced in recipient mice pre-treated with IDO-transduced BMDCs. Furthermore, the expression of inflammatory cytokines such as IL-2, IFNgamma, IL-6, IL-17A and IL-23p19, in splenic T cells of these recipient mice, was significantly lower as compared to that of recipient mice pre-treated with either GFP-transduced BMDCs or untransduced BMDCs.

Steady state dendritic cells with forced IDO expression induce skin allograft tolerance by upregulation of regulatory T cells. Publishing Authors By Initials

G Yu,M Fang,M Gong,L Liu,J Zhong,W Feng,P Xiong,CY Wang,F Gong,G Yu,M Fang,M Gong,L Liu,J Zhong,W Feng,P Xiong,CY Wang,F Gong,

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Steady state dendritic cells with forced IDO expression induce skin allograft tolerance by upregulation of regulatory T cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Transplant immunology

VOLUME: 18

Page Numbers: 208-19

Journal Abbreviation: Transpl. Immunol.

ISSN: 0966-3274

DAY: 10

MONTH: 09

YEAR: 2007

Steady state dendritic cells with forced IDO expression induce skin allograft tolerance by upregulation of regulatory T cells. Information

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LANGUAGE: eng

NlmUniqueID: 9309923

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Grant and Affiliation Information for Steady state dendritic cells with forced IDO expression induce skin allograft tolerance by upregulation of regulatory T cells.

AFFILIATION: Laboratory of Transplantation, Department of Immunology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.

Country: England

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MEDLINETA: Transpl Immunol

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