Staufen-dependent localization of prospero mRNA contributes to neuroblast daughter-cell fate.

Staufen-dependent localization of prospero mRNA contributes to neuroblast daughter-cell fate. Research Abstract Details 

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Staufen-dependent localization of prospero mRNA contributes to neuroblast daughter-cell fate. Abstract Text:

The generation of cellular diversity is essential in embryogenesis, especially in the central nervous system. During neurogenesis, cell interactions or asymmetric protein localization during mitosis can generate daughter cells with different fates. Here we describe the asymmetric localization of a messenger RNA and an RNA-binding protein that creates molecular and developmental differences between Drosophila neural precursors (neuroblasts) and their daughter cells, ganglion mother cells (GMCs). The prospero (pros) mRNA and the RNA-binding protein Staufen (Stau) are asymmetrically localized in mitotic neuroblasts and are specifically partitioned into the GMC, as is Pros protein. Stau is required for localization of pros RNA but not of Pros protein. Loss of localization of Stau or of pros RNA alters GMC development, but only in embryos with reduced levels of Pros protein, suggesting that pros RNA and Pros protein act redundantly to specify GMC fate. We also find that GMCs do not transcribe the pros gene, showing that inheritance of pros RNA and/or Pros protein from the neuroblast is essential for GMC specification.

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Staufen-dependent localization of prospero mRNA contributes to neuroblast daughter-cell fate. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Nature

VOLUME: 391

Page Numbers: 792-5

Journal Abbreviation: Nature

ISSN: 0028-0836

DAY: 19

MONTH: Feb

YEAR: 1998

Staufen-dependent localization of prospero mRNA contributes to neuroblast daughter-cell fate. Information

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LANGUAGE: eng

NlmUniqueID: 410462

Staufen-dependent localization of prospero mRNA contributes to neuroblast daughter-cell fate. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: physiology

Chemical & Substance for Abstract: Staufen-dependent localization of prospero mRNA contributes to neuroblast daughter-cell fate. Information

Substance Name: pros protein, Drosophila

Registry Number: 142540-63-4

Grant and Affiliation Information for Staufen-dependent localization of prospero mRNA contributes to neuroblast daughter-cell fate.

AFFILIATION: Department of Cell & Structural Biology, Howard Hughes Medical Institute, University of Illinois, Urbana 61801, USA.

Country: ENGLAND

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MEDLINETA: Nature

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