Statins benefit outcomes of renal transplant recipients on a sirolimus-cyclosporine regimen.

Statins benefit outcomes of renal transplant recipients on a sirolimus-cyclosporine regimen. Research Abstract Details 

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Statins benefit outcomes of renal transplant recipients on a sirolimus-cyclosporine regimen. Abstract Text:

W Lisik,L Schoenberg,R E Lasky,B D Kahan,W Lisik,L Schoenberg,R E Lasky,B D Kahan,W Lisik,L Schoenberg,R E Lasky,B D Kahan,

BACKGROUND: Statins offer a strategy to address dyslipidemia commonly experienced by immunosuppressed transplant recipients. METHODS: This single-center, retrospective study of 325 recipients (mean posttransplant follow-up of over 6 years; 75.0 +/- 26.0 months) correlated four adverse outcomes-biopsy-confirmed acute rejection episodes, biopsy-confirmed chronic rejection/allograft nephropathy, graft loss, or death-with demographic and posttreatment variables. Patients were treated with a combination of sirolimus (SRL), cyclosporine (CsA), and various durations of steroids. Statins were prescribed for 259/325 (79%) recipients whose serum cholesterol exceeded 240 mg/dL and discontinued when the creatine phosphokinase increased fivefold (3.4%) or the liver function, threefold (3.0%) above normal. RESULTS: Upon univariate (hazard ratio [HR] 0.16; P < .001) and multivariate analysis (HR 0.38; P = .02), statins were markedly protective against acute rejection episodes. They reduced occurrence of chronic nephropathy/chronic rejection (HR 0.60; P = .03 and HR 0.52; P = .01, respectively). Incidences of graft loss were diminished (HR 0.26; P < .001 and HR 0.49; P = .01, respectively). Finally, the mortality rate was decreased (HR 0.21, P = .001 and HR 0.26, P = .01, respectively). Upon multivariate analysis, a reduced incidence of acute rejection was correlated with greater exposure to SRL (HR 0.78, P = .016) and CsA (HR 0.39; P = .006). CONCLUSIONS: This study demonstrated compelling effects of statins against all adverse outcomes among patients treated with SRL-based, CsA-containing regimens. The profoundly dyslipidemic properties of SRL may explain these unique findings compared with previous studies on patients treated with CsA-based regimens.

Statins benefit outcomes of renal transplant recipients on a sirolimus-cyclosporine regimen. Publishing Authors By Initials

W Lisik,L Schoenberg,RE Lasky,BD Kahan,W Lisik,L Schoenberg,RE Lasky,BD Kahan,W Lisik,L Schoenberg,RE Lasky,BD Kahan,

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Statins benefit outcomes of renal transplant recipients on a sirolimus-cyclosporine regimen. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Transplantation proceedings

VOLUME: 39

Page Numbers: 3086-92

Journal Abbreviation: Transplant. Proc.

ISSN: 0041-1345

DAY: 19

MONTH: Dec

YEAR: 2007

Statins benefit outcomes of renal transplant recipients on a sirolimus-cyclosporine regimen. Information

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LANGUAGE: eng

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AFFILIATION: Division of Immunology and Organ Transplantation, The University of Texas Medical School at Houston, Houston, Texas, USA.

Country: United States

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MEDLINETA: Transplant Proc

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