Statins and the endothelium.

Statins and the endothelium. Research Abstract Details 

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Statins and the endothelium. Abstract Text:

Masaaki Ii,Douglas W Losordo,

Statins have been shown to have pleiotropic effects apart from serum lipid-lowering effect in human. One of the major target organs for the effects of statins is the vascular endothelium, which plays an important role in the development of atherosclerosis and angiogenesis. Recent numerous studies have shown that the statins' cholesterol-independent vascular effects appear to involve directly restoring or improving endothelial function by increasing NO production, promoting re-endothelialization after arterial injury, and inhibiting inflammatory responses within the vessel wall that are thought to contribute to atherosclerosis. This review provides an update of the unique effects of statins on endothelial cells including endothelial progenitor cells as well as highlighting the therapeutic potential of statins beyond their established lipid-lowering effects.

Statins and the endothelium. Publishing Authors By Initials

M Ii,DW Losordo,

For similar cells: stem cells research abstracts see: cells: stem cells research

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Statins and the endothelium. Journal Published:

PUBLICATION TYPE: Review

Journal: Vascular pharmacology

VOLUME: 46

Page Numbers: 1-9

Journal Abbreviation: Vascul. Pharmacol.

ISSN: 1537-1891

DAY: 21

MONTH: 06

YEAR: 2006

Statins and the endothelium. Information

Number of References: 107

LANGUAGE: eng

NlmUniqueID: 101130615

Statins and the endothelium. Keywords Mesh Terms:

KEYWORDS: Stem Cells

MESH TERMS: drug effects

Chemical & Substance for Abstract: Statins and the endothelium. Information

Substance Name: Hydroxymethylglutaryl-CoA Reductase Inhi

Registry Number: 0

Grant and Affiliation Information for Statins and the endothelium.

AFFILIATION: Stem Cell Translational Research, RIKEN Center for Developmental Biology, 2-2 Minatojima, Minamimachi, Kobe, Japan. masa331@cdb.riken.jp

Country: United States

AGENCY: United States NHLBI

GRANT: HL57515

ACRONYM: HL

MEDLINETA: Vascul Pharmacol

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