Statins and sepsis.

Statins and sepsis. Research Abstract Details 

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Statins and sepsis. Abstract Text:

F Gao,L Linhartova,A McD Johnston,D R Thickett,F Gao,L Linhartova,A McD Johnston,D R Thickett,

Severe sepsis and septic shock is common and frequently fatal. Over the last few years, the primary treatments demonstrated to improve outcome from several major clinical trials have finally emerged. However, translating these recent therapeutic advances to routine clinical practice has proven controversial, and new approaches of additional strategies are continued to be developed. Given their pleiotropic effects related to many pathophysiological determinants of sepsis, statin therapy could be the next step in the search for adjuvant therapy. A future challenge may be to test both the efficacy and the safety by large randomized controlled clinical trials ascertaining the effects of statins administered at the onset of sepsis and in patients with severe sepsis or septic shock admitted into intensive care units.

Statins and sepsis. Publishing Authors By Initials

F Gao,L Linhartova,AM Johnston,DR Thickett,F Gao,L Linhartova,AM Johnston,DR Thickett,

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Statins and sepsis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: British journal of anaesthesia

VOLUME: 100

Page Numbers: 288-98

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ISSN: 1471-6771

DAY: 15

MONTH: Mar

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 372541

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AFFILIATION: Academic Department of Anaesthesia, Critical Care, and Pain, Heart of England NHS Foundation Trust, University of Warwick, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK. f.g.smith@bham.ac.uk

Country: England

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MEDLINETA: Br J Anaesth

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