Statin use and risk of colorectal cancer.

Statin use and risk of colorectal cancer. Research Abstract Details 

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Statin use and risk of colorectal cancer. Abstract Text:

Patricia F Coogan,Jacquelyn Smith,Lynn Rosenberg,

BACKGROUND: Statins have anticancer activity in various cell types, including colon cancer cells. Although epidemiologic data on the relationship between statin use and the risk of colorectal cancer are limited, one case-control study reported a 50% reduction in colorectal cancer risk among statin users. We conducted a population-based case-control study to assess this association with respect to statin type, dose, and duration of use. METHODS: Case patients with adenocarcinoma of the colon or rectum were ascertained from participating hospitals in Massachusetts and the Massachusetts Cancer Registry from January 1, 2001, through November 30, 2004. Age-, sex-, and precinct-matched control subjects were chosen from Massachusetts town lists. Information on statin use and other relevant data were obtained by telephone interview. We used multivariable conditional logistic regression models to estimate odds ratios (ORs). All tests for statistical significance were two-sided. RESULTS: Among 1809 case patients and 1809 matched control subjects, regular use of statins for at least 3 months was not associated with the risk of colorectal cancer (OR = 0.92, 95% confidence interval [CI] = 0.78 to 1.09). There was no consistent trend across dose or duration of use (e.g., for > or = 10 years of use, OR = 0.86, 95% CI = 0.51 to 1.45). The risk of stage IV cancer was, however, statistically significantly lower among statin users than among nonusers (OR = 0.49, 95% CI = 0.26 to 0.91). There was no evidence of an interaction between statin use and nonsteroidal anti-inflammatory drug use. CONCLUSIONS: Overall, use of statins did not appear to be associated with reduced risk of colorectal cancer. The reduced risk of stage IV cancer observed among statin users requires confirmation.

Statin use and risk of colorectal cancer. Publishing Authors By Initials

PF Coogan,J Smith,L Rosenberg,

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk assessment research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk assessment research

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Statin use and risk of colorectal cancer. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of the National Cancer Institute

VOLUME: 99

Page Numbers: 32-40

Journal Abbreviation: J. Natl. Cancer Inst.

ISSN: 1460-2105

DAY: 3

MONTH: Jan

YEAR: 2007

Statin use and risk of colorectal cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503089

Statin use and risk of colorectal cancer. Keywords Mesh Terms:

KEYWORDS: Risk Assessment

MESH TERMS: epidemiology

Chemical & Substance for Abstract: Statin use and risk of colorectal cancer. Information

Substance Name: Hydroxymethylglutaryl-CoA Reductase Inhi

Registry Number: 0

Grant and Affiliation Information for Statin use and risk of colorectal cancer.

AFFILIATION: Slone Epidemiology Center, Boston University School of Medicine, 1010 Commonwealth Ave., Boston, MA 02215, USA. pcoogan@bu.edu

Country: United States

AGENCY: United States NCI

GRANT: R01CA87709

ACRONYM: CA

MEDLINETA: J Natl Cancer Inst

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