[State of diagnostics and therapy of inflammatory cardiomyopathie.]

[State of diagnostics and therapy of inflammatory cardiomyopathie.] Research Abstract Details 

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[State of diagnostics and therapy of inflammatory cardiomyopathie.] Abstract Text:

H P Schultheiss,U Kühl,

Myocardial inflammation of cardiac muscle is caused by intramyocardial infiltration of immunological competent cells. Etiologically, the relevant factors are the direct or indirect influence of infectious pathogens, toxic, chemical or physical agents, allergic-hyperergic reactions and myocardial inflammatory events in the context of systemic diseases. Clinically significant infections include cardiotropic viruses, which are capable of causing acute or chronic damage to the myocardium under certain conditions. The wide variety of etiologies in inflammatory cardiomyopathy and its heterogeneous clinical presentations have impeded patients identification and consensus on the most appropriate diagnostic criteria and specific therapeutic strategies. Although the Dallas criteria have standardized the histological definition of active myocarditis, the recognition of true etiologies of acute and chronic stages of inflammatory cardiomyopathies require additional and more sensitive markers of tissue inflammation and molecular biological identification of responsible infectious agents. Actually, only biopsy-based diagnosis and characterization of patients allow identification of patients who may get benefit from specific immunosuppressive or anti-viral treatment strategies.

[State of diagnostics and therapy of inflammatory cardiomyopathie.] Publishing Authors By Initials

HP Schultheiss,U Kühl,

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[State of diagnostics and therapy of inflammatory cardiomyopathie.] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Der Internist

VOLUME: 49

Page Numbers: 7-16

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ISSN: 0020-9554

DAY: 11

MONTH: Jan

YEAR: 2008

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LANGUAGE: ger

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AFFILIATION: Medizinische Klinik II, Kardiologie und Pneumonologie, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Deutschland, heinz-peter.schultheiss@charite.de.

Country: Germany

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MEDLINETA: Internist (Berl)

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