State-dependent bidirectional modification of somatic inhibition in neocortical pyramidal cells.

State-dependent bidirectional modification of somatic inhibition in neocortical pyramidal cells. Research Abstract Details 

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State-dependent bidirectional modification of somatic inhibition in neocortical pyramidal cells. Abstract Text:

Tohru Kurotani,Kazumasa Yamada,Yumiko Yoshimura,Michael C Crair,Yukio Komatsu,

Cortical pyramidal neurons alter their responses to input signals depending on behavioral state. We investigated whether changes in somatic inhibition contribute to these alterations. In layer 5 pyramidal neurons of rat visual cortex, repetitive firing from a depolarized membrane potential, which typically occurs during arousal, produced long-lasting depression of somatic inhibition. In contrast, slow membrane oscillations with firing in the depolarized phase, which typically occurs during slow-wave sleep, produced long-lasting potentiation. The depression is mediated by L-type Ca2+ channels and GABA(A) receptor endocytosis, whereas potentiation is mediated by R-type Ca2+ channels and receptor exocytosis. It is likely that the direction of modification is mainly dependent on the ratio of R- and L-type Ca2+ channel activation. Furthermore, somatic inhibition was stronger in slices prepared from rats during slow-wave sleep than arousal. This bidirectional modification of somatic inhibition may alter pyramidal neuron responsiveness in accordance with behavioral state.

State-dependent bidirectional modification of somatic inhibition in neocortical pyramidal cells. Publishing Authors By Initials

T Kurotani,K Yamada,Y Yoshimura,MC Crair,Y Komatsu,

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State-dependent bidirectional modification of somatic inhibition in neocortical pyramidal cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuron

VOLUME: 57

Page Numbers: 905-16

Journal Abbreviation: Neuron

ISSN: 1097-4199

DAY: 27

MONTH: Mar

YEAR: 2008

State-dependent bidirectional modification of somatic inhibition in neocortical pyramidal cells. Information

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LANGUAGE: eng

NlmUniqueID: 8809320

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AFFILIATION: Department of Neuroscience, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan. kurotani@brain.riken.jp

Country: United States

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MEDLINETA: Neuron

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