STAT5 acts as a repressor to regulate early embryonic erythropoiesis.

STAT5 acts as a repressor to regulate early embryonic erythropoiesis. Research Abstract Details 

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STAT5 acts as a repressor to regulate early embryonic erythropoiesis. Abstract Text:

Matthew Schmerer,Ingrid Torregroza,Aude Pascal,Muriel Umbhauer,Todd Evans,

STAT5 regulates definitive (adult stage) erythropoiesis through its ability to transduce signals from the erythropoietin receptor. A function for STAT-dependent signaling during primitive (embryonic) erythropoiesis has not been analyzed. We tested this in the Xenopus system, because STAT5 is expressed at the right time and place to regulate development of the embryonic primitive ventral blood island. Depletion of STAT5 activity results in delayed accumulation of the first globin-expressing cells, indicating that the gene does regulate primitive erythropoiesis. Our results suggest that in this context STAT5 functions as a repressor, since forced expression of an activator isoform blocks erythropoiesis, while embryos expressing a repressor isoform develop normally. The erythroid phenotype caused by the activator isoform of STAT5 resembles that caused by overexpression of fibroblast growth factor (FGF). We show that STAT5 isoforms can function epistatic to FGF and can be phosphorylated in response to hyperactivated FGF signaling in Xenopus embryos. Therefore, our data indicate that STAT5 functions in both primitive and definitive erythropoiesis, but by different mechanisms.

STAT5 acts as a repressor to regulate early embryonic erythropoiesis. Publishing Authors By Initials

M Schmerer,I Torregroza,A Pascal,M Umbhauer,T Evans,

For similar proteins: amphibian proteins: xenopus proteins research abstracts see: proteins: amphibian proteins: xenopus proteins research

PUBMED ID PMID:

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STAT5 acts as a repressor to regulate early embryonic erythropoiesis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Blood

VOLUME: 108

Page Numbers: 2989-97

Journal Abbreviation: Blood

ISSN: 0006-4971

DAY: 11

MONTH: 07

YEAR: 2006

STAT5 acts as a repressor to regulate early embryonic erythropoiesis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7603509

STAT5 acts as a repressor to regulate early embryonic erythropoiesis. Keywords Mesh Terms:

KEYWORDS: Xenopus Proteins

MESH TERMS: genetics

Chemical & Substance for Abstract: STAT5 acts as a repressor to regulate early embryonic erythropoiesis. Information

Substance Name: Fibroblast Growth Factors

Registry Number: 62031-54-3

Grant and Affiliation Information for STAT5 acts as a repressor to regulate early embryonic erythropoiesis.

AFFILIATION: Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL056182

ACRONYM: HL

MEDLINETA: Blood

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