Stable isotope-assisted metabolomics in cancer research.

Stable isotope-assisted metabolomics in cancer research. Research Abstract Details 

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Stable isotope-assisted metabolomics in cancer research. Abstract Text:

Andrew N Lane,Teresa W-M Fan,Richard M Higashi,Andrew N Lane,Teresa W-M Fan,Richard M Higashi,

Stable Isotopes are nontoxic, naturally occurring elemental surrogates that are fully compatible with live organisms, including humans in a clinical setting. The ability to enrich common compounds with rare isotopes such as carbon ((13)C) and nitrogen ((15)N) is the only practical means by which metabolic pathways can be traced, performed by following the fate of individual atoms from the source molecules to products via metabolic transformation. Changes in regulation of pathways are therefore captured by this approach, which leads to deeper understanding of fundamental biochemistry of cancer compared with non-cancerous cells, which can lead to new diagnostic tools. (c) 2008 IUBMB IUBMB Life, 60(2): 124-129, 2008.

Stable isotope-assisted metabolomics in cancer research. Publishing Authors By Initials

AN Lane,TW Fan,RM Higashi,AN Lane,TW Fan,RM Higashi,

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Stable isotope-assisted metabolomics in cancer research. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: IUBMB life

VOLUME: 60

Page Numbers: 124-9

Journal Abbreviation: IUBMB Life

ISSN: 1521-6543

DAY: 1

MONTH: Feb

YEAR: 2008

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LANGUAGE: eng

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AFFILIATION: JG Brown Cancer Center, Louisville, KY, USA.

Country: England

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MEDLINETA: IUBMB Life

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