Stability of refrigerated and frozen solutions of tropisetron in either polyvinylchloride or polyolefin infusion bags.

Stability of refrigerated and frozen solutions of tropisetron in either polyvinylchloride or polyolefin infusion bags. Research Abstract Details 

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Stability of refrigerated and frozen solutions of tropisetron in either polyvinylchloride or polyolefin infusion bags. Abstract Text:

OBJECTIVE: To investigate the stability of 50 microg/ml tropisetron in 0.9% sodium chloride or 5% dextrose injections on storage in either 100 ml polyvinylchloride (Tuliflex) or polyolefin (Clear-flex) infusion bags, at +4 degrees C and -20 degrees C. METHOD: A stability-indicating high-performance liquid chromatography (HPLC) assay was used to measure residual drug at day 0 (D0), D8, D15, D30, D60 and D90 for each bag. Samples were tested for pH at D0, D60 and D90. Frozen samples were thawed in a microwave oven according to a validated procedure before analysis. RESULTS: In 0.9% sodium chloride and 5% dextrose, no degradation products were observed in any of the chromatograms. No admixtures, at any time, contained less than 98.2% of the initial concentration. Only minor changes (-0.12 unit) in pH occurred over the storage period. No colour or other visual changes were seen in any sample. CONCLUSION: Tropisetron (50 microg/ml) in either 0.9% sodium chloride or 5% dextrose is chemically stable in polyvinylchloride or polyolefin bags for at least 3 months when stored in a refrigerator or in a frozen state.

Stability of refrigerated and frozen solutions of tropisetron in either polyvinylchloride or polyolefin infusion bags. Publishing Authors By Initials

For similar pharmaceutical preparations: solutions research abstracts see: pharmaceutical preparations: solutions research

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Stability of refrigerated and frozen solutions of tropisetron in either polyvinylchloride or polyolefin infusion bags. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of clinical pharmacy and therapeutics

VOLUME: 22

Page Numbers: 257-60

Journal Abbreviation: J Clin Pharm Ther

ISSN: 0269-4727

DAY: 28

MONTH: Aug

YEAR: 1997

Stability of refrigerated and frozen solutions of tropisetron in either polyvinylchloride or polyolefin infusion bags. Information

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LANGUAGE: eng

NlmUniqueID: 8704308

Stability of refrigerated and frozen solutions of tropisetron in either polyvinylchloride or polyolefin infusion bags. Keywords Mesh Terms:

KEYWORDS: Solutions

MESH TERMS: chemistry

Chemical & Substance for Abstract: Stability of refrigerated and frozen solutions of tropisetron in either polyvinylchloride or polyolefin infusion bags. Information

Substance Name: Polyvinyl Chloride

Registry Number: 9002-86-2

Grant and Affiliation Information for Stability of refrigerated and frozen solutions of tropisetron in either polyvinylchloride or polyolefin infusion bags.

AFFILIATION: Centre Hospitalier Universitaire, Pharmacie Brabois Adultes, Vandoeuvre-les-Nancy, France.

Country: ENGLAND

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MEDLINETA: J Clin Pharm Ther

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