Stability indicating assay for fetindomide (NSC 373965), a potential prodrug of mitindomide (NSC 284356), employing high-performance liquid chromatography.

Stability indicating assay for fetindomide (NSC 373965), a potential prodrug of mitindomide (NSC 284356), employing high-performance liquid chromatography. Research Abstract Details 

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Stability indicating assay for fetindomide (NSC 373965), a potential prodrug of mitindomide (NSC 284356), employing high-performance liquid chromatography. Abstract Text:

K Umprayn,V J Stella,C M Riley,

A stability indicating assay for fetindomide using reversed-phase high-performance liquid chromatography (HPLC) has been developed. The chromatography was performed on a MOS Hypersil (C(8)) column and was optimized by investigating the effects of methanol (7.5-20%), acetonitrile (5-7%), tetrabutylammonium hydrogen-sulphate (TBA, 0-90 mM) and acetate buffer (pH 3.5, 60-100 mM) on the retention of fetindomide and mitindomide. The optimum mobile phase was 5% acetonitrile in an aqueous solution containing 100 mM acetate buffer (pH 3.5) and 40 mM TBA. Complete resolution of fetindomide, and its degradation products, phenylalanine, the two isomers of N-phenylalanyloxymethylmitindomide and mitindomide was achieved within 10 min at a flow rate of 2 ml/min. The method is linear, accurate and precise for the determination of fetindomide and mitindomide and was applied to study the stability of fetindomide in various aqueous media.

Stability indicating assay for fetindomide (NSC 373965), a potential prodrug of mitindomide (NSC 284356), employing high-performance liquid chromatography. Publishing Authors By Initials

K Umprayn,VJ Stella,CM Riley,

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Stability indicating assay for fetindomide (NSC 373965), a potential prodrug of mitindomide (NSC 284356), employing high-performance liquid chromatography. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of pharmaceutical and biomedical analysis

VOLUME: 5

Page Numbers: 675-85

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ISSN: 0731-7085

DAY: 26

MONTH: 07

YEAR: 1987

Stability indicating assay for fetindomide (NSC 373965), a potential prodrug of mitindomide (NSC 284356), employing high-performance liquid chromatography. Information

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LANGUAGE: eng

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AFFILIATION: Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66045, USA.

Country: England

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MEDLINETA: J Pharm Biomed Anal

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