Stability after freezing and thawing of solutions of mitomycin C in plastic minibags for intravesical use.

Stability after freezing and thawing of solutions of mitomycin C in plastic minibags for intravesical use. Research Abstract Details 

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Stability after freezing and thawing of solutions of mitomycin C in plastic minibags for intravesical use. Abstract Text:

Solutions of 0.6 mg/ml mitomycin C (Mutamycin) in NaCl solution 0.9% in plastic minibags for intravesical use were stored at -20 degrees C and -30 degrees C and thawed by microwave radiation. Both unbuffered solutions and solutions buffered to approximately pH 7.5 were investigated. Concentrations were measured with HPLC. During freezing and storage at -20 degrees C sometimes crystallization of mitomycin C occurred. However, both buffered and unbuffered solutions could be frozen at -30 degrees C during at least four weeks and subsequently thawed without loss of content. Unbuffered mitomycin C solutions could be refrozen at -30 degrees C for another four weeks. Also buffered and unbuffered solutions of another brand of mitomycin C (Mitomycin-C Kyowa) could be frozen at -30 degrees C during four weeks without significant deterioration.

Stability after freezing and thawing of solutions of mitomycin C in plastic minibags for intravesical use. Publishing Authors By Initials

For similar pharmaceutical preparations: solutions research abstracts see: pharmaceutical preparations: solutions research

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MEDLINE DATE:

Stability after freezing and thawing of solutions of mitomycin C in plastic minibags for intravesical use. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pharmaceutisch weekblad. Scientific edition

VOLUME: 8

Page Numbers: 286-8

Journal Abbreviation:

ISSN: 0167-6555

DAY: 12

MONTH: Dec

YEAR: 1986

Stability after freezing and thawing of solutions of mitomycin C in plastic minibags for intravesical use. Information

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LANGUAGE: eng

NlmUniqueID: 7907992

Stability after freezing and thawing of solutions of mitomycin C in plastic minibags for intravesical use. Keywords Mesh Terms:

KEYWORDS: Solutions

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: Stability after freezing and thawing of solutions of mitomycin C in plastic minibags for intravesical use. Information

Substance Name: Mitomycin

Registry Number: 50-07-7

Grant and Affiliation Information for Stability after freezing and thawing of solutions of mitomycin C in plastic minibags for intravesical use.

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Country: NETHERLANDS

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MEDLINETA: Pharm Weekbl Sci

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