SrfB, a member of the Serum Response Factor family of transcription factors, regulates starvation response and early development in Dictyostelium.

SrfB, a member of the Serum Response Factor family of transcription factors, regulates starvation response and early development in Dictyostelium. Research Abstract Details 

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SrfB, a member of the Serum Response Factor family of transcription factors, regulates starvation response and early development in Dictyostelium. Abstract Text:

Galardi-Castilla,Barbara Pergolizzi,Gareth Bloomfield,Jason Skelton,Al Ivens,Robert R Kay,Salvatore Bozzaro,Leandro Sastre,

The Serum Response Factor (SRF) is an important regulator of cell proliferation and differentiation. Dictyostelium discoideum srfB gene codes for an SRF homologue and is expressed in vegetative cells and during development under the control of three alternative promoters, which show different cell-type specific patterns of expression. The two more proximal promoters directed gene transcription in prestalk AB, stalk and lower-cup cells. The generation of a strain where the srfB gene has been interrupted (srfB(-)) has shown that this gene is required for regulation of actin-cytoskeleton-related functions, such as cytokinesis and macropinocytosis. The mutant failed to develop well in suspension, but could be rescued by cAMP pulsing, suggesting a defect in cAMP signaling. srfB(-) cells showed impaired chemotaxis to cAMP and defective lateral pseudopodium inhibition. Nevertheless, srfB(-) cells aggregated on agar plates and nitrocellulose filters 2 h earlier than wild type cells, and completed development, showing an increased tendency to form slug structures. Analysis of wild type and srfB(-) strains detected significant differences in the regulation of gene expression upon starvation. Genes coding for lysosomal and ribosomal proteins, developmentally-regulated genes, and some genes coding for proteins involved in cytoskeleton regulation were deregulated during the first stages of development.

SrfB, a member of the Serum Response Factor family of transcription factors, regulates starvation response and early development in Dictyostelium. Publishing Authors By Initials

M Galardi-Castilla,B Pergolizzi,G Bloomfield,J Skelton,A Ivens,RR Kay,S Bozzaro,L Sastre,

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SrfB, a member of the Serum Response Factor family of transcription factors, regulates starvation response and early development in Dictyostelium. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Developmental biology

VOLUME: 316

Page Numbers: 260-74

Journal Abbreviation: Dev. Biol.

ISSN: 1095-564X

DAY: 31

MONTH: 01

YEAR: 2008

SrfB, a member of the Serum Response Factor family of transcription factors, regulates starvation response and early development in Dictyostelium. Information

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LANGUAGE: eng

NlmUniqueID: 372762

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Grant and Affiliation Information for SrfB, a member of the Serum Response Factor family of transcription factors, regulates starvation response and early development in Dictyostelium.

AFFILIATION: Instituto de Investigaciones Biomédicas CSIC/UAM. Arturo Duperier, 4. 28029 Madrid, Spain.

Country: United States

AGENCY: United Kingdom Wellcome T

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MEDLINETA: Dev Biol

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