Squamous cell carcinomas of the esophagus arise from a telomere-shortened epithelial field.

Squamous cell carcinomas of the esophagus arise from a telomere-shortened epithelial field. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Squamous cell carcinomas of the esophagus arise from a telomere-shortened epithelial field. Abstract Text:

Makoto Kammori,Steven S S Poon,Ken-Ichi Nakamura,Naotaka Izumiyama,Naoshi Ishikawa,Masahiko Kobayashi,Yoshio Naomoto,Kaiyo Takubo,Makoto Kammori,Steven S S Poon,Ken-Ichi Nakamura,Naotaka Izumiyama,Naoshi Ishikawa,Masahiko Kobayashi,Yoshio Naomoto,Kaiyo Takubo,

Critically shortened telomeres make chromosomes susceptible to the instability and widespread cytogenetic alterations that characterize most human cancers. We hypothesized that the very rapid cell proliferation observed in esophageal squamous cell carcinomas might accelerate telomere shortening and chromosomal instability associated with carcinogenesis. We used a number of telomere measurement techniques including quantitative fluorescence in situ hybridization (Q-FISH) to compare chromosomal aberrations and telomere lengths of individual chromosomes in esophageal squamous cell carcinomas (ESCCs) and nearby non-neoplastic esophageal epithelium (NNEE) cells. Our results showed that the mean telomere length in ESCC cells was significantly less than that in adjacent NNEE cells, and that telomeres in all NNEE cells were significantly shorter than those in normal esophageal epithelium (reported previously). In addition, there was no evidence linking telomere shortening of a particular chromosome to field cancerization in ESCC. However, a mechanistic link between telomere shortening and chromosomal instability was supported by a higher frequency of anaphase/telophase bridges and an increase in the frequency of aneuploidy. This study furthers our understanding of the mechanism by which telomere shortening and chromosomal instability lead to carcinogenesis and field cancerization in the esophagus.

Squamous cell carcinomas of the esophagus arise from a telomere-shortened epithelial field. Publishing Authors By Initials

M Kammori,SS Poon,K Nakamura,N Izumiyama,N Ishikawa,M Kobayashi,Y Naomoto,K Takubo,M Kammori,SS Poon,K Nakamura,N Izumiyama,N Ishikawa,M Kobayashi,Y Naomoto,K Takubo,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Squamous cell carcinomas of the esophagus arise from a telomere-shortened epithelial field. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of molecular medicine

VOLUME: 20

Page Numbers: 793-9

Journal Abbreviation: Int. J. Mol. Med.

ISSN: 1107-3756

DAY: 5

MONTH: Dec

YEAR: 2007

Squamous cell carcinomas of the esophagus arise from a telomere-shortened epithelial field. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9810955

Squamous cell carcinomas of the esophagus arise from a telomere-shortened epithelial field. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Squamous cell carcinomas of the esophagus arise from a telomere-shortened epithelial field. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Squamous cell carcinomas of the esophagus arise from a telomere-shortened epithelial field.

AFFILIATION: Division of Breast and Endocrine Surgery, Department of Surgery, Nihon University School of Medicine, Tokyo 173-8610, Japan. kanmori-dis@umin.ac.jp.

Country: Greece

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Int J Mol Med

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Squamous cell carcinomas of the esophagus arise from a telomere-shortened epithelial field Related Publications

• A new method for measuring compound muscle action potentials in facial palsy: A preliminary study.
• Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epithelium.
• CTAD as a universal anticoagulant.
• Comparison between arthroscopic and open synovectomy for the knee in rheumatoid arthritis.
• Detection of citrullinated proteins in synovial fluids derived from patients with rheumatoid arthritis by proteomics-based analysis.
• Immunological aspect of Senear-Usher syndrome.
• Markedly different clinical features in 2 diabetes mellitus patients with extremely high tissue levels of the mitochondrial DNA A3243G mutation.
• Prognostic utility of fluorescence in situ hybridization for determining HER2 gene amplification in breast cancer.
• Squamous cell carcinomas of the esophagus arise from a telomere-shortened epithelial field.