Spontaneous retinal activity mediates development of ocular dominance columns and binocular receptive fields in v1.

Spontaneous retinal activity mediates development of ocular dominance columns and binocular receptive fields in v1. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Spontaneous retinal activity mediates development of ocular dominance columns and binocular receptive fields in v1. Abstract Text:

The mechanisms that give rise to ocular dominance columns (ODCs) during development are controversial. Early experiments indicated a key role for retinal activity in ODC formation. However, later studies showed that in those early experiments, the retinal activity perturbation was initiated after ODCs had already formed. Moreover, recent studies concluded that early eye removals do not impact ODC segregation. Here we blocked spontaneous retinal activity during the very early stages of ODC development. This permanently disrupted the anatomical organization of ODCs and led to a dramatic increase in receptive field size for binocular cells in primary visual cortex. Our data suggest that early spontaneous retinal activity conveys crucial information about whether thalamocortical axons represent one or the other eye and that this activity mediates binocular competition important for shaping receptive fields in primary visual cortex.

Spontaneous retinal activity mediates development of ocular dominance columns and binocular receptive fields in v1. Publishing Authors By Initials

For similar nervous system: neural pathways: afferent pathways: visual pathways research abstracts see: nervous system: neural pathways: afferent pathways: visual pathways research

PUBMED ID PMID:

MEDLINE DATE:

Spontaneous retinal activity mediates development of ocular dominance columns and binocular receptive fields in v1. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neuron

VOLUME: 52

Page Numbers: 247-54

Journal Abbreviation: Neuron

ISSN: 0896-6273

DAY: 19

MONTH: Oct

YEAR: 2006

Spontaneous retinal activity mediates development of ocular dominance columns and binocular receptive fields in v1. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8809320

Spontaneous retinal activity mediates development of ocular dominance columns and binocular receptive fields in v1. Keywords Mesh Terms:

KEYWORDS: Visual Pathways

MESH TERMS: growth & development

Chemical & Substance for Abstract: Spontaneous retinal activity mediates development of ocular dominance columns and binocular receptive fields in v1. Information

Substance Name: epibatidine

Registry Number: 140111-52-0

Grant and Affiliation Information for Spontaneous retinal activity mediates development of ocular dominance columns and binocular receptive fields in v1.

AFFILIATION: Center for Neuroscience, University of California, Davis, Davis, California 95616, USA.

Country: United States

AGENCY: United States NEI

GRANT: EY11369

ACRONYM: EY

MEDLINETA: Neuron

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Spontaneous retinal activity mediates development of ocular dominance columns and binocular receptive fields in v1 Related Publications

• Adjunctive Immunotherapy in Combination with Lipid-associated Amphotericin B for the Treatment of Invasive Candidiasis.
• Adjuvant therapy of melanoma.
• Autosomal dominant polycystic kidney disease: time for a change?
• Bandwidth and fidelity on the NEO-Five Factor Inventory: replicability and reliability of Saucier's (1998) item cluster subcomponents.
• Coil sensitivity estimation for optimal SNR reconstruction and intensity inhomogeneity correction in phased array MR imaging.
• Come to where the flavour is: additives and pesticide residue in cigarettes.
• Concepts and preliminary data toward the realization of image-guided liver surgery.
• Context effects on the spontaneous leg movements of infants with spina bifida.
• Control of coccidiosis into the next millennium.
• Curli biogenesis and function.
• Deterministic loading of individual atoms to a high-finesse optical cavity.
• Diffraction-enhanced imaging of a porcine eye.
• Effects of norgestomet, altrenogest, and/or estradiol on follicular and hormonal characteristics of late transitional mares.
• Employee participation in workplace health promotion and wellness programs: how important are incentives, and which work best?
• Evaluating the effectiveness of four contextual features in classifying annotated clinical conditions in emergency department reports.
• Examples of mathematical modeling: tales from the crypt.
• Falling prevalence of smoking: how low can we go?
• Haptic discrimination of two-dimensional angles: influence of exploratory strategy.
• High-throughput fluorescent multiplex array for indoor allergen exposure assessment.
• In vitro polymerization of a functional Escherichia coli amyloid protein.
• Interleukin-1beta is the primary initiator of pulmonary inflammation following liver injury in mice.
• Is "YouTube" telling or selling you something? Tobacco content on the YouTube video-sharing website.
• Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic.
• Neighborhood Walkability and Income: Associations with Walking for Leisure and Transportation: 644: May 31 8:45 AM 9:00 AM.
• Non-surgical embryo transfer and live birth in a llama.
• Primary aldosteronism in diabetic subjects with resistant hypertension.
• Spontaneous retinal activity mediates development of ocular dominance columns and binocular receptive fields in v1.
• Target Theory Revisited: Why Physicists are Essential for Radiobiology Research.
• The 9-hexadecenoic and 11-octadecenoic acid content of natural fats and oils.
• The curli nucleator protein, CsgB, contains an amyloidogenic domain that directs CsgA polymerization.