Spontaneous fibrillation of the native neuropeptide hormone Somatostatin-14.

Spontaneous fibrillation of the native neuropeptide hormone Somatostatin-14. Research Abstract Details 

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Spontaneous fibrillation of the native neuropeptide hormone Somatostatin-14. Abstract Text:

Wilmar van Grondelle, Iglesias,Elisenda Coll,Franck Artzner, Paternostre, Lacombe,Merce Cardus,Gema Martinez,Martin Montes,Roland Cherif-Cheikh, ,Wilmar van Grondelle, Iglesias,Elisenda Coll,Franck Artzner, Paternostre, Lacombe,Merce Cardus,Gema Martinez,Martin Montes,Roland Cherif-Cheikh, ,

Natural Somatostatin-14 is a small cyclic neuropeptide hormone with broad inhibitory effects on endocrine secretions. Here we show that natural Somatostatin-14 spontaneously self-assembles in water and in 150 mM NaCl into liquid crystalline nanofibrils, which follow characteristic structural features of amyloid fibrils. These non-covalent highly stable structures are based on the Somatostatin native backbone conformation and are formed under non-denaturing conditions. Our results support the hypothesis that self-assembly into amyloid fibrils is a generic property of the polypeptide chain under appropriate conditions. Given recent advances on the mechanisms of biological storage and sorting modes of peptide/protein hormones into secretory granules, we propose that Somatostatin-14 fibrillation could be relevant to the regulated secretion pathway of this neuropeptide hormone. Such a hypothesis is consistent with the emerging concept of the existence of non-disease related but functional amyloids.

Spontaneous fibrillation of the native neuropeptide hormone Somatostatin-14. Publishing Authors By Initials

W van Grondelle,CL Iglesias,E Coll,F Artzner,M Paternostre,F Lacombe,M Cardus,G Martinez,M Montes,R Cherif-Cheikh,C ,W van Grondelle,CL Iglesias,E Coll,F Artzner,M Paternostre,F Lacombe,M Cardus,G Martinez,M Montes,R Cherif-Cheikh,C ,

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Spontaneous fibrillation of the native neuropeptide hormone Somatostatin-14. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of structural biology

VOLUME: 160

Page Numbers: 211-23

Journal Abbreviation: J. Struct. Biol.

ISSN: 1047-8477

DAY: 23

MONTH: 08

YEAR: 2007

Spontaneous fibrillation of the native neuropeptide hormone Somatostatin-14. Information

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LANGUAGE: eng

NlmUniqueID: 9011206

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AFFILIATION: Ipsen Pharma, Carrer Laureà Miró 395, Sant Feliu de Llobregat, 08980 Barcelona, Spain.

Country: United States

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MEDLINETA: J Struct Biol

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