Spliceosomal introns as tools for genomic and evolutionary analysis.

Spliceosomal introns as tools for genomic and evolutionary analysis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Spliceosomal introns as tools for genomic and evolutionary analysis. Abstract Text:

Manuel Irimia,Scott William Roy,

Over the past 5 years, the availability of dozens of whole genomic sequences from a wide variety of eukaryotic lineages has revealed a very large amount of information about the dynamics of intron loss and gain through eukaryotic history, as well as the evolution of intron sequences. Implicit in these advances is a great deal of information about the structure and evolution of surrounding sequences. Here, we review the wealth of ways in which structures of spliceosomal introns as well as their conservation and change through evolution may be harnessed for evolutionary and genomic analysis. First, we discuss uses of intron length distributions and positions in sequence assembly and annotation, and for improving alignment of homologous regions. Second, we review uses of introns in evolutionary studies, including the utility of introns as indicators of rates of sequence evolution, for inferences about molecular evolution, as signatures of orthology and paralogy, and for estimating rates of nucleotide substitution. We conclude with a discussion of phylogenetic methods utilizing intron sequences and positions.

Spliceosomal introns as tools for genomic and evolutionary analysis. Publishing Authors By Initials

M Irimia,SW Roy,

For similar cells: cellular structures: intracellular space: cell nucleus: cell nucleus structures: intranuclear space: spliceosomes research abstracts see: cells: cellular structures: intracellular space: cell nucleus: cell nucleus structures: intranuclear space: spliceosomes research

PUBMED ID PMID:

MEDLINE DATE:

Spliceosomal introns as tools for genomic and evolutionary analysis. Journal Published:

PUBLICATION TYPE: Review

Journal: Nucleic acids research

VOLUME: 36

Page Numbers: 1703-12

Journal Abbreviation: Nucleic Acids Res.

ISSN: 1362-4962

DAY: 7

MONTH: 02

YEAR: 2008

Spliceosomal introns as tools for genomic and evolutionary analysis. Information

Number of References: 115

LANGUAGE: eng

NlmUniqueID: 411011

Spliceosomal introns as tools for genomic and evolutionary analysis. Keywords Mesh Terms:

KEYWORDS: Spliceosomes

MESH TERMS: metabolism

Chemical & Substance for Abstract: Spliceosomal introns as tools for genomic and evolutionary analysis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Spliceosomal introns as tools for genomic and evolutionary analysis.

AFFILIATION: Departament de Genètica, Universitat de Barcelona, Barcelona, Spain.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Nucleic Acids Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Spliceosomal introns as tools for genomic and evolutionary analysis Related Publications

• A novel range based QSAR study of human neuropeptide Y (NPY) Y5 receptor inhibitors.
• Assembly of feline calicivirus-like particle and its immunogenicity.
• Calotropis procera latex extract affords protection against inflammation and oxidative stress in Freund's complete adjuvant-induced monoarthritis in rats.
• Community eye health care for leprosy patients in west bengal, India.
• Comparative protein modeling and surface analysis of Leishmania sirtuin: A potential target for antileishmanial drug discovery.
• Development of primordial follicles in the hamster: role of estradiol-17beta.
• Effector proteins translocated by Legionella pneumophila: strength in numbers.
• Emotional distress in women presenting for breast imaging.
• Enhancing antitumor immunity: combining IL-12 with TGFbeta1 antagonism.
• Evaluation of the clinical decisions made for 2-year-olds referred for speech and language therapy: a follow-up study.
• Explosive Force Production and Fractionated Reaction Time in Elderly Low and High Active Women: 974: June 2 10:45 AM - 11:00 AM.
• Explosive force and fractionated reaction time in elderly low- and high-active women.
• Expression of G protein-coupled receptor 30 in the hamster ovary: differential regulation by gonadotropins and steroid hormones.
• Glossal angiomyoma: Imaging findings and endovascular treatment.
• Glycemic control in critically ill patients effect of delay in insulin administration.
• Harlequin fetus.
• Magnesium, essential for base excision repair enzymes, inhibits substrate binding of N-methylpurine-DNA glycosylase.
• Molecular mechanism of insulin resistance.
• Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression.
• Oxidative DNA damage repair in mammalian cells: a new perspective.
• Perceived hyperoxia: oxygen-induced remodeling of the reoxygenated heart.
• Profiles and correlates of aggressive behaviour among adults with intellectual disabilities.
• Six-year incidence of proteinuria in type 1 diabetic African Americans.
• Surface plasmon resonance as a time-resolved probe of structural changes in molecular films: considerations for correlating resonance shifts with adsorbate layer parameters.
• Survey of clinical engineering in developing countries and model for technology acquisition and diffusion.
• Technical aspects of online hemodiafiltration.
• Tocotrienols: the emerging face of natural vitamin E.
• Transcriptional and epigenetic regulation of interleukin-2 gene in activated T cells by morphine.
• Where people die: a multilevel approach to understanding influences on site of death in America.
• miRNA: licensed to kill the messenger.