Spirulina fusiformis provides protection against mercuric chloride induced oxidative stress in Swiss albino mice.

Spirulina fusiformis provides protection against mercuric chloride induced oxidative stress in Swiss albino mice. Research Abstract Details 

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Spirulina fusiformis provides protection against mercuric chloride induced oxidative stress in Swiss albino mice. Abstract Text:

Mukesh Kumar Sharma,Ambika Sharma,Ashok Kumar,Madhu Kumar,Mukesh Kumar Sharma,Ambika Sharma,Ashok Kumar,Madhu Kumar,Mukesh Kumar Sharma,Ambika Sharma,Ashok Kumar,Madhu Kumar,

Oxidative stress induced by mercuric chloride (5 mg/kg body weight i.p.) in mice substantially increases the lipid peroxidation level along with corresponding decrease in the reduced glutathione and various antioxidant enzymes in liver and increase in serum transaminases activity. Supplementation of Spirulina (800 mg/kg body weight orally, in olive oil, along with mercuric chloride) for 40 days resulted in decreased LPO level, serum glutamate oxaloacetate and serum glutamate pyruvate transaminase activity along with increase in liver GSH level. The activities of antioxidants enzymes superoxide dismutase, catalase and glutathione-S-transferase were also concomitantly restored to near normal level by Spirulina supplementation to mercuric chloride intoxicated mice. The results clearly demonstrate that Spirulina treatment augments the antioxidants defense mechanism in mercuric chloride induced toxicity and provides evidence that it may have a therapeutic role in free radical mediated diseases.

Spirulina fusiformis provides protection against mercuric chloride induced oxidative stress in Swiss albino mice. Publishing Authors By Initials

MK Sharma,A Sharma,A Kumar,M Kumar,MK Sharma,A Sharma,A Kumar,M Kumar,MK Sharma,A Sharma,A Kumar,M Kumar,

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Spirulina fusiformis provides protection against mercuric chloride induced oxidative stress in Swiss albino mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Food and chemical toxicology : an international jo

VOLUME: 45

Page Numbers: 2412-9

Journal Abbreviation: Food Chem. Toxicol.

ISSN: 0278-6915

DAY: 28

MONTH: 06

YEAR: 2007

Spirulina fusiformis provides protection against mercuric chloride induced oxidative stress in Swiss albino mice. Information

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LANGUAGE: eng

NlmUniqueID: 8207483

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Grant and Affiliation Information for Spirulina fusiformis provides protection against mercuric chloride induced oxidative stress in Swiss albino mice.

AFFILIATION: Department of Zoology, RLS Government (PG) College, Kaladera, Jaipur 303801, India. mkshrma@hotmail.com

Country: England

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MEDLINETA: Food Chem Toxicol

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