Spine-type-specific recruitment of newly synthesized AMPA receptors with learning.

Spine-type-specific recruitment of newly synthesized AMPA receptors with learning. Research Abstract Details 

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Spine-type-specific recruitment of newly synthesized AMPA receptors with learning. Abstract Text:

Naoki Matsuo,Leon Reijmers,Mark Mayford,

The stabilization of long-term memories requires de novo protein synthesis. How can proteins, synthesized in the soma, act on specific synapses that participate in a given memory? We studied the dynamics of newly synthesized AMPA-type glutamate receptors (AMPARs) induced with learning using transgenic mice expressing the GluR1 subunit fused to green fluorescent protein (GFP-GluR1) under control of the c-fos promoter. We found learning-associated recruitment of newly synthesized GFP-GluR1 selectively to mushroom-type spines in adult hippocampal CA1 neurons 24 hours after fear conditioning. Our results are consistent with a "synaptic tagging" model to allow activated synapses to subsequently capture newly synthesized receptor and also demonstrate a critical functional distinction in the mushroom spines with learning.

Spine-type-specific recruitment of newly synthesized AMPA receptors with learning. Publishing Authors By Initials

N Matsuo,L Reijmers,M Mayford,

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Spine-type-specific recruitment of newly synthesized AMPA receptors with learning. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Science (New York, N.Y.)

VOLUME: 319

Page Numbers: 1104-7

Journal Abbreviation: Science

ISSN: 1095-9203

DAY: 22

MONTH: Feb

YEAR: 2008

Spine-type-specific recruitment of newly synthesized AMPA receptors with learning. Information

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LANGUAGE: eng

NlmUniqueID: 404511

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Grant and Affiliation Information for Spine-type-specific recruitment of newly synthesized AMPA receptors with learning.

AFFILIATION: Department of Cell Biology and Institute for Childhood and Neglected Diseases, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. n-matsuo@fujita-hu.ac.jp

Country: United States

AGENCY: United States NIMH

GRANT: MH57368

ACRONYM: MH

MEDLINETA: Science

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