Spinal cord neuronal precursors generate multiple neuronal phenotypes in culture.

Spinal cord neuronal precursors generate multiple neuronal phenotypes in culture. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Spinal cord neuronal precursors generate multiple neuronal phenotypes in culture. Abstract Text:

A J Kalyani,D Piper,T Mujtaba,M T Lucero,M S Rao,

Neuronal restricted precursors (NRPs) () can generate multiple neurotransmitter phenotypes during maturation in culture. Undifferentiated E-NCAM+ (embryonic neural cell adhesion molecule) immunoreactive NRPs are mitotically active and electrically immature, and they express only a subset of neuronal markers. Fully mature cells are postmitotic, process-bearing cells that are neurofilament-M and synaptophysin immunoreactive, and they synthesize and respond to different subsets of neurotransmitter molecules. Mature neurons that synthesize and respond to glycine, glutamate, GABA, dopamine, and acetylcholine can be identified by immunocytochemistry, RT-PCR, and calcium imaging in mass cultures. Individual NRPs also generate heterogeneous progeny as assessed by neurotransmitter response and synthesis, demonstrating the multipotent nature of the precursor cells. Differentiation can be modulated by sonic hedgehog (Shh) and bone morphogenetic protein (BMP)-2/4 molecules. Shh acts as a mitogen and inhibits differentiation (including cholinergic differentiation). BMP-2 and BMP-4, in contrast, inhibit cell division and promote differentiation (including cholinergic differentiation). Thus, a single neuronal precursor cell can differentiate into multiple classes of neurons, and this differentiation can be modulated by environmental signals.

Spinal cord neuronal precursors generate multiple neuronal phenotypes in culture. Publishing Authors By Initials

AJ Kalyani,D Piper,T Mujtaba,MT Lucero,MS Rao,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

PUBMED ID PMID:

MEDLINE DATE:

Spinal cord neuronal precursors generate multiple neuronal phenotypes in culture. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of neuroscience : the official journal

VOLUME: 18

Page Numbers: 7856-68

Journal Abbreviation: J. Neurosci.

ISSN: 0270-6474

DAY: 1

MONTH: Oct

YEAR: 1998

Spinal cord neuronal precursors generate multiple neuronal phenotypes in culture. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8102140

Spinal cord neuronal precursors generate multiple neuronal phenotypes in culture. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: drug effects

Chemical & Substance for Abstract: Spinal cord neuronal precursors generate multiple neuronal phenotypes in culture. Information

Substance Name: bone morphogenetic protein 4

Registry Number: 0

Grant and Affiliation Information for Spinal cord neuronal precursors generate multiple neuronal phenotypes in culture.

AFFILIATION: Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA.

Country: UNITED STATES

AGENCY: United States NICHD

GRANT: N01-HD-7-3263

ACRONYM: HD

MEDLINETA: J Neurosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Spinal cord neuronal precursors generate multiple neuronal phenotypes in culture Related Publications

• A common neural progenitor for the CNS and PNS.
• Acute hemorrhagic pancreatic necrosis in mice. Influence of the age and sex of the animals and of dietary ethionine, choline, methionine, and adenine sulfate.
• Age-related functional recruitment for famous name recognition: an event-related fMRI study.
• An FMRI analysis of the human hippocampus: inference, context, and task awareness.
• An Intelligent 802.11 Triage Tag for medical response to disasters.
• Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex.
• Changes in Behavior and Brain Acetylcholinesterase Activity in Mosquito Fish, Gambusia affinis in Response to the Sub-Lethal Exposure to Chlorpyrifos.
• Development and Validation of Liquid Chromatographic and UV Derivative Spectrophotometric Methods for the Determination of Famciclovir in Pharmaceutical Dosage Forms.
• Effect of glycerol level in Tris-basek extender and equilibration period on quality of frozen goat semen.
• Embryonic expression and extracellular secretion of Xenopus slit.
• Evaluation of Cytotoxic Effects of Dichloromethane Extract of Guduchi (Tinospora cordifolia Miers ex Hook F & THOMS) on Cultured HeLa Cells.
• Inhibition by the bioflavonoid ternatin of aflatoxin B1-induced lipid peroxidation in rat liver.
• Ion imprinted polymer particles for separation of yttrium from selected lanthanides.
• Medial temporal lobe activity for recognition of recent and remote famous names: an event-related fMRI study.
• Outbreak of killer brain disease in children.
• Perspectives in medical education--1. Reflections on the state of medical education in Japan.
• Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons.
• Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes.
• Spinal cord neuronal precursors generate multiple neuronal phenotypes in culture.
• THE ORNITHOPHILIC BLACK FLY SIMULIUM MERIDIONALE RILEY (DIPTERA: SIMULIIDAE) FEEDING IN MAN DURING AUTUMN.
• The expression of TNF-alpha mRNA and its significance in murine viral myocarditis.
• The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors.
• The secreted product of Xenopus gene lunatic Fringe, a vertebrate signaling molecule.
• [Analysis of diffuse large B-cell lymphoma heterogeneity based on coupled two-way clustering]
• [Effect of acrylamide on creatine kinase and adenosine triphosphate in brain of mice and its significance]
• [Inhibitive effects of gastric cancer cell-dendritic cell fusion vaccine on tumor cell proliferation cycle]
• [Ion-exchange chromatographic behavior and characterization of Staphylococcus aureus in exponential phase]
• [Major constituent proteins in donkey hide and their interaction]
• [Reaction of atrazine with protein and its application to detection of protein]
• fMRI of healthy older adults during Stroop interference.