Spermatinamine, the first natural product inhibitor of isoprenylcysteine carboxyl methyltransferase, a new cancer target.

Spermatinamine, the first natural product inhibitor of isoprenylcysteine carboxyl methyltransferase, a new cancer target. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Spermatinamine, the first natural product inhibitor of isoprenylcysteine carboxyl methyltransferase, a new cancer target. Abstract Text:

Malcolm S Buchanan,Anthony R Carroll,Gregory A Fechner,Anthony Boyle,Moana M Simpson,Rama Addepalli,Vicky M Avery,John N A Hooper,Nancy Su,Huawei Chen,Ronald J Quinn,Malcolm S Buchanan,Anthony R Carroll,Gregory A Fechner,Anthony Boyle,Moana M Simpson,Rama Addepalli,Vicky M Avery,John N A Hooper,Nancy Su,Huawei Chen,Ronald J Quinn,Malcolm S Buchanan,Anthony R Carroll,Gregory A Fechner,Anthony Boyle,Moana M Simpson,Rama Addepalli,Vicky M Avery,John N A Hooper,Nancy Su,Huawei Chen,Ronald J Quinn,

Isoprenylcysteine methyltransferase (Icmt) catalyzes the carboxyl methylation of oncogenic proteins in the final step of a series of post-translational modifications. The inhibition of Icmt provides an attractive and novel anticancer target. A natural product high-throughput screening campaign was conducted to discover inhibitors of Icmt. The Australian marine sponge, Pseudoceratina sp., yielded spermatinamine, a novel alkaloid with a bromotyrosyl-spermine-bromotyrosyl sequence, as the bioactive constituent. Its structure was determined by 1D and 2D NMR spectroscopy. Spermatinamine is the first natural product inhibitor of Icmt.

Spermatinamine, the first natural product inhibitor of isoprenylcysteine carboxyl methyltransferase, a new cancer target. Publishing Authors By Initials

MS Buchanan,AR Carroll,GA Fechner,A Boyle,MM Simpson,R Addepalli,VM Avery,JN Hooper,N Su,H Chen,RJ Quinn,MS Buchanan,AR Carroll,GA Fechner,A Boyle,MM Simpson,R Addepalli,VM Avery,JN Hooper,N Su,H Chen,RJ Quinn,MS Buchanan,AR Carroll,GA Fechner,A Boyle,MM Simpson,R Addepalli,VM Avery,JN Hooper,N Su,H Chen,RJ Quinn,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Spermatinamine, the first natural product inhibitor of isoprenylcysteine carboxyl methyltransferase, a new cancer target. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 6860-3

Journal Abbreviation:

ISSN: 0960-894X

DAY: 16

MONTH: 10

YEAR: 2007

Spermatinamine, the first natural product inhibitor of isoprenylcysteine carboxyl methyltransferase, a new cancer target. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9107377

Spermatinamine, the first natural product inhibitor of isoprenylcysteine carboxyl methyltransferase, a new cancer target. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Spermatinamine, the first natural product inhibitor of isoprenylcysteine carboxyl methyltransferase, a new cancer target. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Spermatinamine, the first natural product inhibitor of isoprenylcysteine carboxyl methyltransferase, a new cancer target.

AFFILIATION: Eskitis Institute, Griffith University, Brisbane, Qld 4111, Australia.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Bioorg Med Chem Lett

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Spermatinamine, the first natural product inhibitor of isoprenylcysteine carboxyl methyltransferase, a new cancer target Related Publications

• A role for eyebrows in regulating the visibility of eye gaze direction.
• Alpha-melanocyte stimulating hormone peptide-targeted melanoma imaging.
• Comments on the analysis of some triacid triglyceride mixtures.
• Comparative efficacy of nucleoside/nucleotide reverse transcriptase inhibitors in combination with efavirenz: results of a systematic overview.
• Contact Lenses in Pediatrics (CLIP) Study: chair time and ocular health.
• Epithelial-mesenchymal interconversions in normal ovarian surface epithelium and ovarian carcinomas: an exception to the norm.
• Gender and cleaner production: toward a framework for including gender analysis when developing strategies and designing solutions.
• Generation of a transgenic model to address regulation and function of the human neurokinin 1 receptor (NK1R).
• High-throughput screening for small-molecule activators of neutrophils: identification of novel N-formyl peptide receptor agonists.
• Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems.
• Infants' sensitivity to uniform connectedness as a cue for perceptual organization.
• Melanoma imaging with pretargeted bivalent bacteriophage.
• N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase.
• Nitric oxide-NGF mediated PPTA/SP, ADNP, and VIP expression in the peripheral nervous system.
• Osteoclast inhibitory lectin (OCIL) inhibits osteoblast differentiation and function in vitro.
• Passivating protein coatings for implantable glucose sensors: evaluation of protein retention.
• Pharmacological treatment of heart failure.
• Reducing health disparities in depressive disorders outcomes between non-Hispanic Whites and ethnic minorities: a call for pragmatic strategies over the life course.
• Reducing renal uptake of 90Y- and 177Lu-labeled alpha-melanocyte stimulating hormone peptide analogues.
• Retinopathy of prematurity in Brazil: an emerging problem.
• Review: advance provision of emergency contraception increases its use but does not reduce unplanned pregnancies.
• Role of NF-kappaB in transcriptional regulation of the phagocyte NADPH oxidase by tumor necrosis factor-alpha.
• Spina bifida advocacy--a case study in public policy success.
• Systemic reaction rates to field stings among imported fire ant-sensitive patients receiving >3 years of immunotherapy versus <3 years of immunotherapy.
• The future in advanced prostate cancer: take your partners or is the last dance for me?
• The purification and specificity of a lipase fromVernonia anthelmintica seed.
• Therapeutic efficacy of a 177Lu-labeled DOTA conjugated alpha-melanocyte-stimulating hormone peptide in a murine melanoma-bearing mouse model.
• Trachoma and ocular Chlamydia trachomatis were not eliminated three years after two rounds of mass treatment in a trachoma hyperendemic village.
• Trench entrapment: is ketamine safe to use for sedation in head injury?
• Uterine innervation in fibroids: a qualitative study.