[Sperm sex chromosome analysis and preimplantation genetic diagnosis of patients with sex chromosome anomalies]

[Sperm sex chromosome analysis and preimplantation genetic diagnosis of patients with sex chromosome anomalies] Research Abstract Details 

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[Sperm sex chromosome analysis and preimplantation genetic diagnosis of patients with sex chromosome anomalies] Abstract Text:

Yan-wen Xu,Xiu-lian Ren,Can-quan Zhou,Hui-ping Li,Yin Liu,Min-fang Zhang,Guang-lun Zhuang,

OBJECTIVE: To investigate the constitution of abnormal spermatozoa from patients with sex chromosome anomalies. METHODS: Triple color fluorescence in situ hybridization (FISH) was used to determine the sex chromosome constitution of spermatozoa from three patients with sex chromosome anomalies (case 1:46,XY/47,XXY, case 2:45,XO/46,X,Yqh-, case 3:47,XXY). The preimplantation genetic diagnosis (PGD) was performed to case 2. RESULTS: An increased ratio (2.05 vs 1) of X-bearing to Y-bearing spermatozoa was only observed in case 2, who also had an increased incidence of total abnormal spermatozoa (29.71%). An increased incidence of total abnormal spermatozoa (4.91%) was also observed in case 3. Among the constitution of abnormal spermatozoa, case 2 had the increased proportions of XY18 disomy, O18 monosomy and XO monosomy, while case 3 had an increase proportion of XY18 disomy (1.87%). PGD was performed to case 2 and one embryo with XX1818 was selected for implanting. CONCLUSION: Using FISH to detect the sperm sex chromosomes in patients with sex chromosome anomalies can provide the useful information to evaluate the risk of sex chromosome anomalies in preimplantation embryos.

[Sperm sex chromosome analysis and preimplantation genetic diagnosis of patients with sex chromosome anomalies] Publishing Authors By Initials

YW Xu,XL Ren,CQ Zhou,HP Li,Y Liu,MF Zhang,GL Zhuang,

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[Sperm sex chromosome analysis and preimplantation genetic diagnosis of patients with sex chromosome anomalies] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yix

VOLUME: 23

Page Numbers: 431-3

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ISSN: 1003-9406

DAY: 2

MONTH: Aug

YEAR: 2006

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LANGUAGE: chi

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AFFILIATION: Reproductive Research Center, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, P. R. China.

Country: China

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MEDLINETA: Zhonghua Yi Xue Yi Chuan Xue Z

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