Sperm mitochondria and fertilisation.

Sperm mitochondria and fertilisation. Research Abstract Details 

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Sperm mitochondria and fertilisation. Abstract Text:

Justin C St John,Emma J Bowles,Alexandra Amaral,

Human mitochondrial DNA (mtDNA) is an extranuclear genome that encodes 13 of the polypeptides associated with the process of oxidative phosphorylation (OXPHOS). The role and importance of OXPHOS in sperm motility and function has been debated over the last few years. Here, we argue that sperm OXPHOS is important to sperm function in the light of clinical based evidence in the human where pathogenic mutations have also been described in sperm and are associated with varying degrees of male subfertility. We also discuss the importance of maintaining maternal inheritance of mtDNA and how sperm mtDNA might be eliminated during early embryogenesis in a manner similar to the process which decreases oocyte mtDNA to extremely low levels once it reaches the blastocyst stage of preimplantation development. Finally, we discuss the role of sperm mtDNA replication and why it may be prudent to considerably reduce sperm mtDNA numbers during the transition from spermatogenesis to spermiogenesis.

Sperm mitochondria and fertilisation. Publishing Authors By Initials

JC St John,EJ Bowles,A Amaral,

For similar urogenital system: genitalia: germ cells: spermatozoa research abstracts see: urogenital system: genitalia: germ cells: spermatozoa research

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Sperm mitochondria and fertilisation. Journal Published:

PUBLICATION TYPE: Review

Journal: Society of Reproduction and Fertility supplement

VOLUME: 65

Page Numbers: 399-416

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DAY: 19

MONTH: 11

YEAR: 2007

Sperm mitochondria and fertilisation. Information

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LANGUAGE: eng

NlmUniqueID: 101295315

Sperm mitochondria and fertilisation. Keywords Mesh Terms:

KEYWORDS: Spermatozoa

MESH TERMS: ultrastructure

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Grant and Affiliation Information for Sperm mitochondria and fertilisation.

AFFILIATION: Mitochondrial and Reproductive Genetics Group, The Medical School, University of Birmingham, Birmingham B15 2TT, UK. j.stjohn.1@bham.ac.uk

Country: England

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MEDLINETA: Soc Reprod Fertil Suppl

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