[Spectroscopic studies on the interactions of a hexadeca-carboxy zinc phthalocyanine and serum albumin and preparation of the bioconjugates]

[Spectroscopic studies on the interactions of a hexadeca-carboxy zinc phthalocyanine and serum albumin and preparation of the bioconjugates] Research Abstract Details 

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[Spectroscopic studies on the interactions of a hexadeca-carboxy zinc phthalocyanine and serum albumin and preparation of the bioconjugates] Abstract Text:

Yan-Mei Chen,Jian-Dong Huang,Feng-Ran Liu,Rui-Qing Sun,Dennis K P Ng,

The interactions of the new photosensitizer {2, 3, 9, 10, 16, 17, 23, 24-octakis[(3,5-dicarboxy)phenoxy]-phthalocyaninato}zinc(II) [ZnPc(COOH)16] and serum albumins (BSA and HSA) were investigated by absorption and fluorescence spectroscopy. The binding constants were found to be 2.25-2.94 x 10(6) L x mol(-1). The 1 : 1 ZnPc (COOH)16-BSA and ZnPc (COOH)16-BSA conjugates were also prepared by incubating a mixture of ZnPc(COOH)16 and the corresponding serum albumin in 2 : 1 mole ratio followed by separation by gel permeation chromatography. The Q band absorption and fluorescence emission of ZnPc(COOH)16 are slightly red-shifted in the conjugates, and the spectral features suggest that the phthalocyanine exists predominantly in monomeric form in the conjugates.

[Spectroscopic studies on the interactions of a hexadeca-carboxy zinc phthalocyanine and serum albumin and preparation of the bioconjugates] Publishing Authors By Initials

YM Chen,JD Huang,FR Liu,RQ Sun,DK Ng,

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[Spectroscopic studies on the interactions of a hexadeca-carboxy zinc phthalocyanine and serum albumin and preparation of the bioconjugates] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Guang pu xue yu guang pu fen xi = Guang pu

VOLUME: 26

Page Numbers: 1387-91

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ISSN: 1000-0593

DAY: 24

MONTH: Aug

YEAR: 2006

[Spectroscopic studies on the interactions of a hexadeca-carboxy zinc phthalocyanine and serum albumin and preparation of the bioconjugates] Information

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LANGUAGE: chi

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AFFILIATION: College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China.

Country: China

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MEDLINETA: Guang Pu Xue Yu Guang Pu Fen X

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