Spectral Clustering of fMRI Data within Regions of Interest: Clarification of L-dopa effects in Parkinson's Disease.

Spectral Clustering of fMRI Data within Regions of Interest: Clarification of L-dopa effects in Parkinson's Disease. Research Abstract Details 

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Spectral Clustering of fMRI Data within Regions of Interest: Clarification of L-dopa effects in Parkinson's Disease. Abstract Text:

Pamela W H Lee,Z Wang,Samantha J Palmer,Martin J McKeown,Pamela W H Lee,Z Wang,Samantha J Palmer,Martin J McKeown,

Identifying active regions of the brain that are task-related is important in fMRI study. Current methods of determining functional Regions of Interest (ROIs) are unsatisfactory because they either reduce the effect size or bias the statistical results. We propose a spectral clustering method for assessing those voxels within an ROI that are suitable for further task-activation analysis. Different similarity functions are studied and the correlation index is chosen based on the simulation study. In real fMRI study, further group analysis employing regression is investigated to identify different brain activation patterns between groups in order to reveal the effects of disease and medicine. A real fMRI case study in Parkinson's disease suggests that the technique is promising, warranting further study.

Spectral Clustering of fMRI Data within Regions of Interest: Clarification of L-dopa effects in Parkinson's Disease. Publishing Authors By Initials

PW Lee,Z Wang,SJ Palmer,MJ McKeown,PW Lee,Z Wang,SJ Palmer,MJ McKeown,

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Spectral Clustering of fMRI Data within Regions of Interest: Clarification of L-dopa effects in Parkinson's Disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Conference proceedings : ... Annual International

VOLUME: 1

Page Numbers: 5235-8

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ISSN: 1557-170X

DAY: 16

MONTH: 11

YEAR: 2007

Spectral Clustering of fMRI Data within Regions of Interest: Clarification of L-dopa effects in Parkinson's Disease. Information

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LANGUAGE: eng

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AFFILIATION: Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, BC, Canada. e-mail: wpamelal@interchange.ubc.ca.

Country: United States

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MEDLINETA: Conf Proc IEEE Eng Med Biol So

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