Specificities of acetoxy derivatives of coumarins, biscoumarins, chromones, flavones, isoflavones and xanthones for acetoxy drug: protein transacetylase.

Specificities of acetoxy derivatives of coumarins, biscoumarins, chromones, flavones, isoflavones and xanthones for acetoxy drug: protein transacetylase. Research Abstract Details 

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Specificities of acetoxy derivatives of coumarins, biscoumarins, chromones, flavones, isoflavones and xanthones for acetoxy drug: protein transacetylase. Abstract Text:

Ajit Kumar,Brajendra K Singh,Nawal K Sharma,Kapil Gyanda,Sapan K Jain,Yogesh K Tyagi,Anil S Baghel,Mukesh Pandey,Sunil K Sharma,Ashok K Prasad,Subhash C Jain,Ramesh C Rastogi,Hanumantharao G Raj,Arthur C Watterson,Erik Van der Eycken,Virinder S Parmar,Ajit Kumar,Brajendra K Singh,Nawal K Sharma,Kapil Gyanda,Sapan K Jain,Yogesh K Tyagi,Anil S Baghel,Mukesh Pandey,Sunil K Sharma,Ashok K Prasad,Subhash C Jain,Ramesh C Rastogi,Hanumantharao G Raj,Arthur C Watterson,Erik Van der Eycken,Virinder S Parmar,

The earlier work carried out in our laboratory led to the identification of a novel rat liver microsomal enzyme termed as acetoxy drug: protein transacetylase (TAase), catalyzing the transfer of acetyl group from polyphenolic acetates (PA) to functional proteins. In this paper, we have reported the comparison of the specificities of acetoxy derivatives of coumarins, biscoumarins, chromones, flavones, isoflavones and xanthones with special reference to the phenyl moiety/bulky group on the pyran ring of PA. The results clearly indicated that compounds having phenyl moieties, when used as the substrates, resulted in a significant reduction of TAase catalyzed activity. The alteration in TAase catalyzed activation of NADPH cytochrome c reductase and inhibition of benzene-induced micronuclei in bone marrow cells by PA were in tune with their specificities to TAase.

Specificities of acetoxy derivatives of coumarins, biscoumarins, chromones, flavones, isoflavones and xanthones for acetoxy drug: protein transacetylase. Publishing Authors By Initials

A Kumar,BK Singh,NK Sharma,K Gyanda,SK Jain,YK Tyagi,AS Baghel,M Pandey,SK Sharma,AK Prasad,SC Jain,RC Rastogi,HG Raj,AC Watterson,E Van der Eycken,VS Parmar,A Kumar,BK Singh,NK Sharma,K Gyanda,SK Jain,YK Tyagi,AS Baghel,M Pandey,SK Sharma,AK Prasad,SC Jain,RC Rastogi,HG Raj,AC Watterson,E Van der Eycken,VS Parmar,

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Specificities of acetoxy derivatives of coumarins, biscoumarins, chromones, flavones, isoflavones and xanthones for acetoxy drug: protein transacetylase. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of medicinal chemistry

VOLUME: 42

Page Numbers: 447-55

Journal Abbreviation:

ISSN: 0223-5234

DAY: 19

MONTH: 12

YEAR: 2006

Specificities of acetoxy derivatives of coumarins, biscoumarins, chromones, flavones, isoflavones and xanthones for acetoxy drug: protein transacetylase. Information

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LANGUAGE: eng

NlmUniqueID: 420510

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Grant and Affiliation Information for Specificities of acetoxy derivatives of coumarins, biscoumarins, chromones, flavones, isoflavones and xanthones for acetoxy drug: protein transacetylase.

AFFILIATION: Department of Biochemistry, V P Chest Institute, University of Delhi, Delhi 110 007, India.

Country: France

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MEDLINETA: Eur J Med Chem

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