Specification of individual Slouch muscle progenitors in Drosophila requires sequential Wingless signaling.

Specification of individual Slouch muscle progenitors in Drosophila requires sequential Wingless signaling. Research Abstract Details 

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Specification of individual Slouch muscle progenitors in Drosophila requires sequential Wingless signaling. Abstract Text:

The patterning of the Drosophila mesoderm requires Wingless (Wg), one of the founding members of a large family of secreted glycoproteins, the Wnt family. Little is known about how Wg provides patterning information to the mesoderm, which is neither an epithelium nor contains the site of Wg production. By studying specification of muscle founder cells as marked by the lineage-specific transcription factor Slouch, we asked how mesodermal cells interpret the steady flow of Wg. Through the manipulation of place, time and amount of Wg signaling, we have observed that Slouch founder cell cluster II is more sensitive to Wg levels than the other Slouch-positive founder cell clusters. To specify Slouch cluster I, Wg signaling is required to maintain high levels of the myogenic transcriptional regulator Twist. However, to specify cluster II, Wg not only maintains high Twist levels, but also provides a second contribution to activate Slouch expression. This dual requirement for Wg provides a paradigm for understanding how one signaling pathway can act over time to create a diverse array of patterning outcomes.

Specification of individual Slouch muscle progenitors in Drosophila requires sequential Wingless signaling. Publishing Authors By Initials

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Specification of individual Slouch muscle progenitors in Drosophila requires sequential Wingless signaling. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Development (Cambridge, England)

VOLUME: 132

Page Numbers: 713-24

Journal Abbreviation: Development

ISSN: 0950-1991

DAY: 12

MONTH: 01

YEAR: 2005

Specification of individual Slouch muscle progenitors in Drosophila requires sequential Wingless signaling. Information

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LANGUAGE: eng

NlmUniqueID: 8701744

Specification of individual Slouch muscle progenitors in Drosophila requires sequential Wingless signaling. Keywords Mesh Terms:

KEYWORDS: Stem Cells

MESH TERMS: metabolism

Chemical & Substance for Abstract: Specification of individual Slouch muscle progenitors in Drosophila requires sequential Wingless signaling. Information

Substance Name: wg protein, Drosophila

Registry Number: 0

Grant and Affiliation Information for Specification of individual Slouch muscle progenitors in Drosophila requires sequential Wingless signaling.

AFFILIATION: Program in Developmental Biology, Weill Graduate School of Medical Sciences at Cornell University and Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA.

Country: England

AGENCY: United States NIGMS

GRANT: GM56989

ACRONYM: GM

MEDLINETA: Development

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