Specification of cell fate along the proximal-distal axis in the developing chick limb bud.

Specification of cell fate along the proximal-distal axis in the developing chick limb bud. Research Abstract Details 

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Specification of cell fate along the proximal-distal axis in the developing chick limb bud. Abstract Text:

Kosei Sato,Yutaka Koizumi,Masanori Takahashi,Atsushi Kuroiwa,Koji Tamura,

Pattern formation along the proximal-distal (PD) axis in the developing limb bud serves as a good model for learning how cell fate and regionalization of domains, which are essential processes in morphogenesis during development, are specified by positional information. In the present study, detailed fate maps for the limb bud of the chick embryo were constructed in order to gain insights into how cell fate for future structures along the PD axis is specified and subdivided. Our fate map revealed that there is a large overlap between the prospective autopod and zeugopod in the distal limb bud at an early stage (stage 19), whereas a limb bud at this stage has already regionalized the proximal compartments for the prospective stylopod and zeugopod. A clearer boundary of cell fate specifying the prospective autopod and zeugopod could be seen at stage 23, but cell mixing was still detectable inside the prospective autopod region at this stage. Detailed analysis of HOXA11 AND HOXA13 expression at single cell resolution suggested that the cell mixing is not due to separation of some different cell populations existing in a mosaic. Our findings suggest that a mixable unregionalized cell population is maintained in the distal area of the limb bud, while the proximal region starts to be regionalized at the early stage of limb development.

Specification of cell fate along the proximal-distal axis in the developing chick limb bud. Publishing Authors By Initials

K Sato,Y Koizumi,M Takahashi,A Kuroiwa,K Tamura,

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Specification of cell fate along the proximal-distal axis in the developing chick limb bud. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Development (Cambridge, England)

VOLUME: 134

Page Numbers: 1397-406

Journal Abbreviation: Development

ISSN: 0950-1991

DAY: 28

MONTH: 02

YEAR: 2007

Specification of cell fate along the proximal-distal axis in the developing chick limb bud. Information

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LANGUAGE: eng

NlmUniqueID: 8701744

Specification of cell fate along the proximal-distal axis in the developing chick limb bud. Keywords Mesh Terms:

KEYWORDS: Reverse Transcriptase Polymerase Chain R

MESH TERMS: metabolism

Chemical & Substance for Abstract: Specification of cell fate along the proximal-distal axis in the developing chick limb bud. Information

Substance Name: homeobox protein HOXA13

Registry Number: 0

Grant and Affiliation Information for Specification of cell fate along the proximal-distal axis in the developing chick limb bud.

AFFILIATION: Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aobayama, Aoba-ku, Sendai 980-8578, Japan.

Country: England

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MEDLINETA: Development

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