Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signature.

Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signature. Research Abstract Details 

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Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signature. Abstract Text:

Itziar Salaverria,Andreas Zettl, ,Victor Moreno,Joan Valls,Elena Hartmann,German Ott,George Wright,Armando Lopez-Guillermo,Wing C Chan,Dennis D Weisenburger,Randy D Gascoyne,Thomas M Grogan,Jan Delabie,Elaine S Jaffe,Emili Montserrat,Hans-Konrad Muller-Hermelink,Louis M Staudt,Andreas Rosenwald,Elias Campo,

PURPOSE: To compare the genetic relationship between cyclin D1-positive and cyclin D1-negative mantle cell lymphomas (MCLs) and to determine whether specific genetic alterations may add prognostic information to survival prediction based on the proliferation signature of MCLs. PATIENTS AND METHODS: Seventy-one cyclin D1-positive and six cyclin D1-negative MCLs previously characterized by gene expression profiling were examined by comparative genomic hybridization (CGH). RESULTS: Cyclin D1-negative MCLs were genetically characterized by gains of 3q, 8q, and 15q, and losses of 1p, 8p23-pter, 9p21-pter, 11q21-q23, and 13q that were also the most common alterations in conventional MCLs. Parallel analysis of CGH aberrations and locus-specific gene expression profiles in cyclin D1-positive patients showed that chromosomal imbalances had a substantial impact on the expression levels of the genes located in the altered regions. The analysis of prognostic factors revealed that the proliferation signature, the number of chromosomal aberrations, gains of 3q, and losses of 8p, 9p, and 9q predicted survival of MCL patients. A multivariate analysis showed that the gene expression-based proliferation signature was the strongest predictor for shorter survival. However, 3q gains and 9q losses provided prognostic information that was independent of the proliferative activity. CONCLUSION: Cyclin D1-positive and -negative MCLs share the same secondary genetic aberrations, supporting the concept that they correspond to the same genetic entity. The integration of genetic information on chromosome 3q and 9q alterations into a proliferation signature-based model may improve the ability to predict survival in patients with MCL.

Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signature. Publishing Authors By Initials

I Salaverria,A Zettl,S ,V Moreno,J Valls,E Hartmann,G Ott,G Wright,A Lopez-Guillermo,WC Chan,DD Weisenburger,RD Gascoyne,TM Grogan,J Delabie,ES Jaffe,E Montserrat,HK Muller-Hermelink,LM Staudt,A Rosenwald,E Campo,

For similar diagnosis: prognosis research abstracts see: diagnosis: prognosis research

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Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signature. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of clinical oncology : official journal of

VOLUME: 25

Page Numbers: 1216-22

Journal Abbreviation: J. Clin. Oncol.

ISSN: 1527-7755

DAY: 12

MONTH: 02

YEAR: 2007

Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signature. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8309333

Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signature. Keywords Mesh Terms:

KEYWORDS: Prognosis

MESH TERMS: pathology

Chemical & Substance for Abstract: Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signature. Information

Substance Name: Cyclin D1

Registry Number: 136601-57-5

Grant and Affiliation Information for Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signature.

AFFILIATION: Department of Pathology and Hematology, Hospital Clinic, University of Barcelona, Barcelona, Spain.

Country: United States

AGENCY: United States NCI

GRANT: UO1-CA84967

ACRONYM: CA

MEDLINETA: J Clin Oncol

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