[Specific humoral immuneresponse in Rhesus monkeys vaccinated immune response with Abeta42 peptide vaccine]

[Specific humoral immuneresponse in Rhesus monkeys vaccinated immune response with Abeta42 peptide vaccine] Research Abstract Details 

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[Specific humoral immuneresponse in Rhesus monkeys vaccinated immune response with Abeta42 peptide vaccine] Abstract Text:

Shao-bing Li,Hua-qiao Wang,Xian Lin,Jie Xu,Zhi-bin Yao,

AIM: To observe the humoral immuneresponse in Rhesus monkey induced by Abeta42 peptide vaccination. METHODS: Five male Rhesus monkeys were received intramuscular injection of Abeta42 peptide vaccine at 0, 2nd, 6th, 10th, 14th, 18th, 22th week. The titers and Ig subclasses of the serum anti-Abeta42 antibody were measured by ELISA. The specificity of the anti-Abeta42 antibody was determined by Western blot. The recognition of Abeta plaques in Tg2576-transgenic mouse brain tissue by anti-Abeta42 serum were detected by immunohistochemical staining. RESULTS: At the 8th week after the vaccination, the serum anti-Abeta42 antibody was detected. The titers of the antibody increased with times of booster inoculation and reached 1:4,320 at the 24th week, then decreased. The produced antibodies were mainly IgG1 and IgG2(IgG2/IgG1>1). The anti-Abeta42 antibody had high specificity. The Abeta plaques in Tg2576-transgenic mouse brain tissue were recognized by the antisera. CONCLUSION: Abeta42 peptide vaccine can induce effectively specific humoral immuneresponse in Rhesus monkey.

[Specific humoral immuneresponse in Rhesus monkeys vaccinated immune response with Abeta42 peptide vaccine] Publishing Authors By Initials

SB Li,HQ Wang,X Lin,J Xu,ZB Yao,

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[Specific humoral immuneresponse in Rhesus monkeys vaccinated immune response with Abeta42 peptide vaccine] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese jour

VOLUME: 21

Page Numbers: 202-4

Journal Abbreviation: Xi Bao Yu Fen Zi Mian Yi Xue Z

ISSN: 1007-8738

DAY: 15

MONTH: Mar

YEAR: 2005

[Specific humoral immuneresponse in Rhesus monkeys vaccinated immune response with Abeta42 peptide vaccine] Information

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LANGUAGE: chi

NlmUniqueID: 101139110

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AFFILIATION: Department of Anatomy, Zhongshan Medical College, SUN Yat-Sen University, Guangzhou 510080, China.

Country: China

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MEDLINETA: Xi Bao Yu Fen Zi Mian Yi Xue Z

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