Special regulatory T-cell review: FOXP3 biochemistry in regulatory T cells - how diverse signals regulate suppression.

Special regulatory T-cell review: FOXP3 biochemistry in regulatory T cells - how diverse signals regulate suppression. Research Abstract Details 

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Special regulatory T-cell review: FOXP3 biochemistry in regulatory T cells - how diverse signals regulate suppression. Abstract Text:

Bin Li,Mark I Greene,Bin Li,Mark I Greene,Bin Li,Mark I Greene,

FOXP3 is an acetylated and phosphorylated protein active in human regulatory T cells and forms oligomers which then associate with an even larger molecular complex. FOXP3 actively regulates transcription by recruiting enzymatic co-repressors and/or co-activators. FOXP3 complex ensembles are dynamically regulated by physiological stimuli such as T-cell receptor, IL-2 and proinflammation cytokine signals. Understanding the post-translational modifications of FOXP3 regulated by diverse signals and the biochemistry and structural chemistry of enzymatic proteins in the FOXP3 complex is critical for therapeutically modulating regulatory T cell function.

Special regulatory T-cell review: FOXP3 biochemistry in regulatory T cells - how diverse signals regulate suppression. Publishing Authors By Initials

B Li,MI Greene,B Li,MI Greene,B Li,MI Greene,

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Special regulatory T-cell review: FOXP3 biochemistry in regulatory T cells - how diverse signals regulate suppression. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Immunology

VOLUME: 123

Page Numbers: 17-9

Journal Abbreviation: Immunology

ISSN: 1365-2567

DAY: 24

MONTH: Jan

YEAR: 2008

Special regulatory T-cell review: FOXP3 biochemistry in regulatory T cells - how diverse signals regulate suppression. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Special regulatory T-cell review: FOXP3 biochemistry in regulatory T cells - how diverse signals regulate suppression.

AFFILIATION: Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Country: England

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MEDLINETA: Immunology

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