SPDEF regulates goblet cell hyperplasia in the airway epithelium.

SPDEF regulates goblet cell hyperplasia in the airway epithelium. Research Abstract Details 

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SPDEF regulates goblet cell hyperplasia in the airway epithelium. Abstract Text:

Kwon-Sik Park,Thomas R Korfhagen,Michael D Bruno,Joseph A Kitzmiller,Huajing Wan,Susan E Wert,Gurjit K Khurana Hershey,Gang Chen,Jeffrey A Whitsett,

Goblet cell hyperplasia and mucous hypersecretion contribute to the pathogenesis of chronic pulmonary diseases including cystic fibrosis, asthma, and chronic obstructive pulmonary disease. In the present work, mouse SAM pointed domain-containing ETS transcription factor (SPDEF) mRNA and protein were detected in subsets of epithelial cells lining the trachea, bronchi, and tracheal glands. SPDEF interacted with the C-terminal domain of thyroid transcription factor 1, activating transcription of genes expressed selectively in airway epithelial cells, including Sftpa, Scgb1a1, Foxj1, and Sox17. Expression of Spdef in the respiratory epithelium of adult transgenic mice caused goblet cell hyperplasia, inducing both acidic and neutral mucins in vivo, and stainined for both acidic and neutral mucins in vivo. SPDEF expression was increased at sites of goblet cell hyperplasia caused by IL-13 and dust mite allergen in a process that was dependent upon STAT-6. SPDEF was induced following intratracheal allergen exposure and after Th2 cytokine stimulation and was sufficient to cause goblet cell differentiation of Clara cells in vivo.

SPDEF regulates goblet cell hyperplasia in the airway epithelium. Publishing Authors By Initials

KS Park,TR Korfhagen,MD Bruno,JA Kitzmiller,H Wan,SE Wert,GK Khurana Hershey,G Chen,JA Whitsett,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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SPDEF regulates goblet cell hyperplasia in the airway epithelium. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of clinical investigation

VOLUME: 117

Page Numbers: 978-88

Journal Abbreviation: J. Clin. Invest.

ISSN: 0021-9738

DAY: 8

MONTH: 03

YEAR: 2007

SPDEF regulates goblet cell hyperplasia in the airway epithelium. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7802877

SPDEF regulates goblet cell hyperplasia in the airway epithelium. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: physiology

Chemical & Substance for Abstract: SPDEF regulates goblet cell hyperplasia in the airway epithelium. Information

Substance Name: Ttf1 protein, mouse

Registry Number: 0

Grant and Affiliation Information for SPDEF regulates goblet cell hyperplasia in the airway epithelium.

AFFILIATION: Division of Pulmonary Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL56387

ACRONYM: HL

MEDLINETA: J Clin Invest

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