Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation.

Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation. Research Abstract Details 

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Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation. Abstract Text:

Ruth R Chen,Eduardo A Silva,William W Yuen,David J Mooney,

PURPOSE: Biological mechanisms of tissue regeneration are often complex, involving the tightly coordinated spatial and temporal presentation of multiple factors. We investigated whether spatially compartmentalized and sequential delivery of factors can be used to pattern new blood vessel formation. MATERIALS AND METHODS: A porous bi-layered poly(lactide-co-glycolide) (PLG) scaffold system was used to locally present vascular endothelial growth factor (VEGF) alone in one spatial region, and sequentially deliver VEGF and platelet-derived growth factor (PDGF) in an adjacent region. Scaffolds were implanted in severely ischemic hindlimbs of SCID mice for 2 and 6 weeks, and new vessel formation was quantified within the scaffolds. RESULTS: In the compartment delivering a high dose of VEGF alone, a high density of small, immature blood vessels was observed at 2 weeks. Sequential delivery of VEGF and PDGF led to a slightly lower blood vessel density, but vessel size and maturity were significantly enhanced. Results were similar at 6 weeks, with continued remodeling of vessels in the VEGF and PDGF layer towards increased size and maturation. CONCLUSIONS: Spatially localizing and temporally controlling growth factor presentation for angiogenesis can create spatially organized tissues.

Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation. Publishing Authors By Initials

RR Chen,EA Silva,WW Yuen,DJ Mooney,

For similar peptides: intercellular signaling peptides and proteins: angiogenic proteins: vascular endothelial growth factors: vascular endothelial growth factor a research abstracts see: peptides: intercellular signaling peptides and proteins: angiogenic proteins: vascular endothelial growth factors: vascular endothelial growth factor a research

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Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Pharmaceutical research

VOLUME: 24

Page Numbers: 258-64

Journal Abbreviation: Pharm. Res.

ISSN: 0724-8741

DAY: 27

MONTH: 12

YEAR: 2006

Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8406521

Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation. Keywords Mesh Terms:

KEYWORDS: Vascular Endothelial Growth Factor A

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation. Information

Substance Name: Vascular Endothelial Growth Factor A

Registry Number: 0

Grant and Affiliation Information for Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation.

AFFILIATION: Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL069957

ACRONYM: HL

MEDLINETA: Pharm Res

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