Spatially discordant voltage alternans cause wavebreaks in ventricular fibrillation.

Spatially discordant voltage alternans cause wavebreaks in ventricular fibrillation. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Spatially discordant voltage alternans cause wavebreaks in ventricular fibrillation. Abstract Text:

Raymond E Ideker,Derek J Dosdall,Peter G Robertson,Jack M Rogers,

BACKGROUND: Ventricular fibrillation (VF) is characterized by complex ECG patterns emanating from multiple, short-lived, reentrant electrical waves. The incessant breakup and creation of new daughter waves (wavebreaks) perpetuate VF. Dispersion of refractoriness (static or dynamic) has been implicated as a mechanism underlying wavebreaks. OBJECTIVE: The purpose of this study was to investigate the mechanisms underlying wavefront instability in VF by localizing wave fractionation sites (the appearance of multiple waves) and their relationship to local spatial dispersion of voltage (V(m)) oscillations. METHODS: Wave fractionations were identified by tracking V(m) oscillations optically at unprecedented spatial (100 x 100 pixels) and temporal (2,000 frames per second) resolution using a CMOS camera viewing the surface (1 x 1 cm(2)) of perfused guinea pig hearts (n = 6). VF was induced by burst stimulation, and wavefront dynamics were highlighted using region-based image analysis to automatically detect wavebreaks. Direct detection of wavebreak locations by image analysis was more reliable than the phase reconstruction method because baseline noise obstructed the correct identification of phase singularities by detecting false-positives. RESULTS: Wave fractionations (34 +/- 4 splits/s.cm(2)) fell into three categories: decremental conduction (49% +/- 7%), wave collisions (32% +/- 8%), and wavebreaks (17 +/- 2%). Wavebreaks occurred at a frequency of 5.8 +/- 1 splits/s.cm(2) and did not preferentially occur at anatomic obstacles (i.e., coronary vessels) but coincided with discordant alternans where V(m) amplitudes and durations shifted from high to low to from low to high on opposite sides of wavebreak sites. CONCLUSION: Spatial discordant alternans cause wavebreaks most likely because they are sites of abrupt dispersion of refractoriness.

Spatially discordant voltage alternans cause wavebreaks in ventricular fibrillation. Publishing Authors By Initials

RE Ideker,DJ Dosdall,PG Robertson,JM Rogers,

For similar cardiovascular diseases: heart diseases: arrhythmias, cardiac: ventricular fibrillation research abstracts see: cardiovascular diseases: heart diseases: arrhythmias, cardiac: ventricular fibrillation research

PUBMED ID PMID:

MEDLINE DATE:

Spatially discordant voltage alternans cause wavebreaks in ventricular fibrillation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Heart rhythm : the official journal of the Heart R

VOLUME: 4

Page Numbers: 1057-68

Journal Abbreviation:

ISSN: 1547-5271

DAY: 12

MONTH: 06

YEAR: 2007

Spatially discordant voltage alternans cause wavebreaks in ventricular fibrillation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101200317

Spatially discordant voltage alternans cause wavebreaks in ventricular fibrillation. Keywords Mesh Terms:

KEYWORDS: Ventricular Fibrillation

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Spatially discordant voltage alternans cause wavebreaks in ventricular fibrillation. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Spatially discordant voltage alternans cause wavebreaks in ventricular fibrillation.

AFFILIATION: Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. bchoi@lifespan.org

Country: United States

AGENCY: United States NHLBI

GRANT: HL70722

ACRONYM: HL

MEDLINETA: Heart Rhythm

REFSOURCE: Heart Rhythm. 2007 Aug;4(8):1069-71

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Spatially discordant voltage alternans cause wavebreaks in ventricular fibrillation Related Publications

• A highly sensitive particle agglutination assay for the detection of P53 autoantibodies in patients with lung cancer.
• A rapid gel agglutination test for the determination of fetomaternal haemorrhage.
• Application of the particle gel agglutination assay in the typing of single human leucocyte antigens.
• Application of the particle gel agglutination system as a new check gel assay for PCR products.
• Association between alloantibody specificity and autoantibodies to red blood cells.
• Autoimmune thrombocytopenia in two patients with Sneddon's Syndrome.
• Autonomic nerve stimulation reverses ventricular repolarization sequence in rabbit hearts.
• Calcium transients modulate action potential repolarizations in ventricular fibrillation.
• Design optimization methodology for dry EEG spikes array electrode.
• Dreams and dreaming. Part one.
• Dreams and dreaming. Part two.
• Dual-dye optical mapping after myocardial infarction: does the site of ventricular stimulation alter the properties of electrical propagation?
• Effects of marjoram volatile oil and grape seed extract on ethanol toxicity in male rats.
• Enhanced aqueous solubility of long wavelength voltage-sensitive dyes by covalent attachment of polyethylene glycol.
• Hughes-Stovin syndrome: is it incomplete Behçet's? Report of two cases and review of the literature.
• Identification of Helicobacter pylori genes that contribute to stomach colonization.
• Identification of a novel HLA-DQB1 allele, HLA-DQB1*0632.
• Immune tolerance induction in patients with IgA anaphylactoid reactions following long-term intravenous IgG treatment.
• Iridoid Glucosides from Euphrasia rostkoviana.
• Monte Carlo Simulation of 3D Mapping of Cardiac Electrical Activity with Spinning Slit Confocal Optics.
• Occurrence and overlap of natural disasters, complex emergencies and epidemics during the past decade (1995-2004).
• Optimum storage conditions for cord blood-derived hematopoietic progenitor cells prior to isolation.
• Production of proinflammatory cytokines: granulocyte-macrophage colony stimulating factor, interleukin-8 and interleukin-6 by peripheral blood mononuclear cells of protein energy malnourished children.
• Ridge preservation and augmentation using regenerative materials to enhance implant predictability and esthetics.
• Sleep, physiology and disorders.
• Spatially discordant voltage alternans cause wavebreaks in ventricular fibrillation.
• Studies on the mechanism of action of sulfanilamide on mycelial felts of Rhizoctonia solani.
• Thyroid disorders and autoantibodies in systemic lupus erythematosus and rheumatoid arthritis patients.
• Using genomic microarrays to study insertional/transposon mutant libraries.
• [Aquired immune hemolytic anemias]