Spatial organization of neuronal population responses in layer 2/3 of rat barrel cortex.

Spatial organization of neuronal population responses in layer 2/3 of rat barrel cortex. Research Abstract Details 

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Spatial organization of neuronal population responses in layer 2/3 of rat barrel cortex. Abstract Text:

Jason N D Kerr,Christiaan P J de Kock,David S Greenberg,Randy M Bruno,Bert Sakmann,Fritjof Helmchen,Jason N D Kerr,Christiaan P J de Kock,David S Greenberg,Randy M Bruno,Bert Sakmann,Fritjof Helmchen,

Individual pyramidal neurons of neocortex show sparse and variable responses to sensory stimuli in vivo. It has remained unclear how this variability extends to population responses on a trial-to-trial basis. Here, we characterized single-neuron and population responses to whisker stimulation in layer 2/3 (L2/3) of identified columns in rat barrel cortex using in vivo two-photon calcium imaging. Optical detection of single action potentials from evoked calcium transients revealed low spontaneous firing rates (0.25 Hz), variable response probabilities (range, 0-0.5; mean, 0.2 inside barrel column), and weak angular tuning of L2/3 neurons. On average, both the single-neuron response probability and the percentage of the local population activated were higher in the barrel column than above septa or in neighboring columns. Within the barrel column, mean response probability was highest in the center (0.4) and declined toward the barrel border. Neuronal pairs showed correlations in both spontaneous and sensory-evoked activity that depended on the location of the neurons. Correlation decreased with increasing distance between neurons and, for neuronal pairs the same distance apart, with distance of the pair from the barrel column center. Although neurons are therefore not activated independently from each other, we did not observe precisely repeating spatial activation patterns. Instead, population responses showed large trial-to-trial variability. Nevertheless, the accuracy of decoding stimulus onset times from local population activity increased with population size and depended on anatomical location. We conclude that, despite their sparseness and variability, L2/3 population responses show a clear spatial organization on the columnar scale.

Spatial organization of neuronal population responses in layer 2/3 of rat barrel cortex. Publishing Authors By Initials

JN Kerr,CP de Kock,DS Greenberg,RM Bruno,B Sakmann,F Helmchen,JN Kerr,CP de Kock,DS Greenberg,RM Bruno,B Sakmann,F Helmchen,

For similar animal structures: vibrissae research abstracts see: animal structures: vibrissae research

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Spatial organization of neuronal population responses in layer 2/3 of rat barrel cortex. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of neuroscience : the official journal

VOLUME: 27

Page Numbers: 13316-28

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 28

MONTH: Nov

YEAR: 2007

Spatial organization of neuronal population responses in layer 2/3 of rat barrel cortex. Information

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LANGUAGE: eng

NlmUniqueID: 8102140

Spatial organization of neuronal population responses in layer 2/3 of rat barrel cortex. Keywords Mesh Terms:

KEYWORDS: Vibrissae

MESH TERMS: physiology

Chemical & Substance for Abstract: Spatial organization of neuronal population responses in layer 2/3 of rat barrel cortex. Information

Substance Name: Calcium

Registry Number: 7440-70-2

Grant and Affiliation Information for Spatial organization of neuronal population responses in layer 2/3 of rat barrel cortex.

AFFILIATION: Department of Cell Physiology, Max Planck Institute for Medical Research, D-69120 Heidelberg, Germany. jason@tuebingen.mpg.de

Country: United States

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MEDLINETA: J Neurosci

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